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Protein

Alanine racemase

Gene

dadX

Organism
Rickettsiales bacterium Ac37b
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (dadX)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei258Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei306Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:dadXImported
ORF Names:NOVO_01960Imported
OrganismiRickettsiales bacterium Ac37bImported
Taxonomic identifieri1528098 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsiales
Proteomesi
  • UP000028936 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 363Ala_racemase_CInterPro annotationAdd BLAST127

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A077FHB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYADAILN VDLNSIVYNY LFLKKKLNTV ECGAVVKANA YGIGANHVAS
60 70 80 90 100
TLAKYGCKHF FVANLEEAIS LRAILTKQYN IYVLHGVFPN QEQEFIHYNL
110 120 130 140 150
TPILNDIYQI KIWNCFASTK KIQLPAILYI DTGLSRLGLT TYDALDLFYN
160 170 180 190 200
QTLVANLNIL YLMSHLSAAD NPTHPLNAEQ LKKMSIIQKY MPNTHITFVN
210 220 230 240 250
SSGIFLGTNY HFHLARPGMA LYGLNPTPQS KNPMHNVIYL SSKIIQVRNN
260 270 280 290 300
IKQSPVGYGG SYYAERNSVI ATVAIGYADG YFRSLSNNSI CYINGYKAPV
310 320 330 340 350
IGRVSMDLIT LDVTNVPAHF IYPGQSVEII GDNITVDQLA KYANTLGYEI
360 370
LTNLGHRFKL VYNIDIQLND I
Length:371
Mass (Da):41,546
Last modified:October 29, 2014 - v1
Checksum:i24BD437EBE21A607
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP009217 Genomic DNA. Translation: AIL64787.1.
RefSeqiWP_038602112.1. NZ_CP009217.1.

Genome annotation databases

EnsemblBacteriaiAIL64787; AIL64787; NOVO_01960.
KEGGirbt:NOVO_01960.

Entry informationi

Entry nameiA0A077FHB9_9RICK
AccessioniPrimary (citable) accession number: A0A077FHB9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 29, 2014
Last sequence update: October 29, 2014
Last modified: September 27, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported