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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Porphyromonas sp. 31_2
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotationSAAS annotation
1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.UniRule annotationSAAS annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (HMPREF1002_04558)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAmino-acid biosynthesis, Histidine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00007.
UPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIEUniRule annotation
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
Short name:
PRA-CHUniRule annotation
Phosphoribosyl-ATP pyrophosphataseUniRule annotation (EC:3.6.1.31UniRule annotation)
Short name:
PRA-PHUniRule annotation
Gene namesi
Name:hisIUniRule annotation
Synonyms:hisIEUniRule annotation
ORF Names:HMPREF1002_03060Imported
OrganismiPorphyromonas sp. 31_2Imported
Taxonomic identifieri658663 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000027795 Componenti: Unassembled WGS sequence

Subcellular locationi

A0A073I2U7:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A073I2U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 98PRA-CHInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 108Phosphoribosyl-AMP cyclohydrolaseUniRule annotationAdd BLAST108
Regioni109 – 198Phosphoribosyl-ATP pyrophosphohydrolaseUniRule annotationAdd BLAST90

Sequence similaritiesi

In the C-terminal section; belongs to the PRA-PH family.UniRule annotationSAAS annotation
In the N-terminal section; belongs to the PRA-CH family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd11534. NTP-PPase_HisIE_like. 1 hit.
HAMAPiMF_01020. HisE. 1 hit.
MF_01019. HisIE. 1 hit.
InterProiView protein in InterPro
IPR023019. His_synth_HisIE.
IPR008179. HisE.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase_dom.
PfamiView protein in Pfam
PF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002610. PRA_CycHdrlase. 1 hit.
TIGRFAMsiTIGR03188. histidine_hisI. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A073I2U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLDFEKMGG LIPAIVQDNN TSKVLMLGFM NQEAYDETVS TGKVTFFSRT
60 70 80 90 100
KNRLWMKGES SGNTLQVVSI TADCDNDTLL IKAIPAGPVC HTGADTCFGE
110 120 130 140 150
KNVEDIMFLK YLQNFIERRR QEMPEGSYTT TLFQKGVNRM AQKVGEEAVE
160 170 180 190
TVIEATNGTE DGFIYEASDL VYHLIVLLTS KGLRLEDLAR ELKKRHKG
Length:198
Mass (Da):22,197
Last modified:October 1, 2014 - v1
Checksum:i6150972746676FDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACUD01000009 Genomic DNA. Translation: KEJ83786.1.

Genome annotation databases

EnsemblBacteriaiKEJ83786; KEJ83786; HMPREF1002_03060.
PATRICifig|658663.3.peg.3683.

Similar proteinsi

Entry informationi

Entry nameiA0A073I2U7_9PORP
AccessioniPrimary (citable) accession number: A0A073I2U7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: October 25, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported, Multifunctional enzymeUniRule annotationSAAS annotation