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Protein

LexA repressor

Gene

lexA

Organism
Corynebacterium glutamicum ATCC 14067
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177For autocatalytic cleavage activityUniRule annotation1
Active sitei214For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi56 – 76H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotationSAAS annotation
Biological processDNA damage, DNA repair, DNA replicationUniRule annotationSAAS annotation, SOS responseUniRule annotationSAAS annotation, Transcription, Transcription regulationUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotationSAAS annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
ORF Names:KIQ_012900Imported
OrganismiCorynebacterium glutamicum ATCC 14067Imported
Taxonomic identifieri1079988 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000003642 Componenti: Unassembled WGS sequence

PTM / Processingi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei142 – 143Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavageUniRule annotation

Expressioni

Gene expression databases

CollecTFiEXPREG_00000020.

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 93LexA_DNA_bindInterPro annotationAdd BLAST63
Domaini172 – 235Peptidase_S24InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPiMF_00015. LexA. 1 hit.
InterProiView protein in InterPro
IPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A072Z841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIEKKPAGA RGSRGSRTVK TLPNGKPDPA SLSDRQRRIL EVIRDAVVLR
60 70 80 90 100
GYPPSIREIG DAAGLQSTSS VAYQLKELEK KGFLRRDPNK PRAVDVRHLP
110 120 130 140 150
ETESRSSKAA TQAKSKAPQA GVHDPELAGQ TSFVPVVGKI AAGSPITAEQ
160 170 180 190 200
NIEEYYPLPA EIVGDGDLFM LQVVGESMRD AGILTGDWVV VRSQPVAEQG
210 220 230 240 250
EFVAAMIDGE ATVKEFHKDS SGIWLLPHND TFAPIPAENA EIMGKVVSVM

RKL
Length:253
Mass (Da):27,300
Last modified:October 1, 2014 - v1
Checksum:i385F0047E5A832FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGQQ02000002 Genomic DNA. Translation: KEI23423.1.
RefSeqiWP_003857389.1. NZ_AGQQ02000002.1.

Genome annotation databases

EnsemblBacteriaiKEI23423; KEI23423; KIQ_012900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGQQ02000002 Genomic DNA. Translation: KEI23423.1.
RefSeqiWP_003857389.1. NZ_AGQQ02000002.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKEI23423; KEI23423; KIQ_012900.

Gene expression databases

CollecTFiEXPREG_00000020.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPiMF_00015. LexA. 1 hit.
InterProiView protein in InterPro
IPR006200. LexA.
IPR006199. LexA_DNA-bd_dom.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
PRINTSiPR00726. LEXASERPTASE.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR00498. lexA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A072Z841_CORGT
AccessioniPrimary (citable) accession number: A0A072Z841
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: April 12, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.