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Protein

Putrescine aminotransferase

Gene

patA

Organism
Escherichia coli O145:H25 str. 07-3858
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
ORF Names:BU56_08935Imported
OrganismiEscherichia coli O145:H25 str. 07-3858Imported
Taxonomic identifieri1446583 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000027826 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA0A070D6Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A070D6Q8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALNREVIE YFKEHVNPGF LEYRKSVTAG GDYGAVEWQA GSLNTLVDTQ
60 70 80 90 100
GQEFIDCLGG FGIFNVGHRN PVVVSAVQNQ LAKQPLHSQE LLDPLRAMLA
110 120 130 140 150
KTLAALTPGK LKYSFFCNSG TESVEAALKL AKAYQSPRGK FTFIATSGAF
160 170 180 190 200
HGKSLGALSA TAKSTFRKPF MPLLPGFRHV PFGNIEAMRT ALNECKKTGD
210 220 230 240 250
DVAAVILEPI QGEGGVILPP PGYLTAVRKL CDEFGALMIL DEVQTGMGRT
260 270 280 290 300
GKMFACEHEN VQPDILCLAK ALGGGVMPIG ATIATEEVFS VLFDNPFLHT
310 320 330 340 350
TTFGGNPLAC AAALATINVL LEQNLPAQAD QKGDMLLDGF RQLAREYPDL
360 370 380 390 400
VQEARGKGML MAIEFVDNEI GYNFASEMFR QRVLVAGTLN NAKTIRIEPP
410 420
LTLTIEQCEL VIKAARKALA AMRVSVEEA
Length:429
Mass (Da):46,387
Last modified:October 1, 2014 - v1
Checksum:iDEB0B8277DBEC77A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JASO01000010 Genomic DNA. Translation: KDV36696.1.

Genome annotation databases

EnsemblBacteriaiKDV36696; KDV36696; BU56_08935.

Similar proteinsi

Entry informationi

Entry nameiA0A070D6Q8_ECOLX
AccessioniPrimary (citable) accession number: A0A070D6Q8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: September 27, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported