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Protein

Signal recognition particle receptor FtsY

Gene

ftsY

Organism
Escherichia coli 3-373-03_S4_C2
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi300 – 307GTPUniRule annotation8
Nucleotide bindingi382 – 386GTPUniRule annotation5
Nucleotide bindingi446 – 449GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor FtsYUniRule annotation
Short name:
SRP receptorUniRule annotation
Gene namesi
Name:ftsYUniRule annotationImported
ORF Names:AD17_1983Imported
OrganismiEscherichia coli 3-373-03_S4_C2Imported
Taxonomic identifieri1444252 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000027892 Componenti: Unassembled WGS sequence

Subcellular locationi

A0A069XN98:
  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A069XN98.
SMRiA0A069XN98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 480SRP54InterPro annotationAdd BLAST14

Domaini

Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).UniRule annotation

Sequence similaritiesi

Belongs to the GTP-binding SRP family. FtsY subfamily.UniRule annotation

Family and domain databases

HAMAPiMF_00920. FtsY. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR027417. P-loop_NTPase.
IPR013822. Signal_recog_particl_SRP54_hlx.
IPR004390. SR_rcpt_FtsY.
IPR036225. SRP/SRP_N_dom.
IPR000897. SRP54_GTPase_dom.
PANTHERiPTHR43134:SF2. PTHR43134:SF2. 1 hit.
PfamiView protein in Pfam
PF00448. SRP54. 1 hit.
PF02881. SRP54_N. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00962. SRP54. 1 hit.
SM00963. SRP54_N. 1 hit.
SUPFAMiSSF47364. SSF47364. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00064. ftsY. 1 hit.
PROSITEiView protein in PROSITE
PS00300. SRP54. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A069XN98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKKRGFF SWLGFGQKEQ TPEKETEVQN EQPVVEEIVQ AQEPVKASEQ
60 70 80 90 100
AVEEQPQAHT EAEAETFAAD VVEVTEQVAE SEKAQPEAEV VAQPEPVVEE
110 120 130 140 150
TPEPVAIERE ELPLPEDVNA EAVSPEEWQA EAETVEIVEA AEEEAAKEEI
160 170 180 190 200
TDEELETALA AEAAEEAVMV VPPAEEEQPV EEIAQEQEKP TKEGFFARLK
210 220 230 240 250
RSLLKTKENL GSGFISLFRG KKIDDDLFEE LEEQLLIADV GVETTRKIIT
260 270 280 290 300
NLTEGASRKQ LRDAEALYGL LKEEMGEILA KVDEPLNVEG KAPFVILMVG
310 320 330 340 350
VNGVGKTTTI GKLARQFEQQ GKSVMLAAGD TFRAAAVEQL QVWGQRNNIP
360 370 380 390 400
VIAQHTGADS ASVIFDAIQA AKARNIDVLI ADTAGRLQNK SHLMEELKKI
410 420 430 440 450
VRVMKKLDVE APHEVMLTID ASTGQNAVSQ AKLFHEAVGL TGITLTKLDG
460 470 480 490
TAKGGVIFSV ADQFGIPIRY IGVGERIEDL RPFKADDFIE ALFARED
Length:497
Mass (Da):54,513
Last modified:October 1, 2014 - v1
Checksum:iEBE640072B5D1021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JNMS01000007 Genomic DNA. Translation: KDU31210.1.
RefSeqiWP_001040654.1. NZ_JNMS01000007.1.

Genome annotation databases

EnsemblBacteriaiKDU31210; KDU31210; AD17_1983.
PATRICifig|1444252.3.peg.1950.

Similar proteinsi

Entry informationi

Entry nameiA0A069XN98_ECOLX
AccessioniPrimary (citable) accession number: A0A069XN98
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2014
Last sequence update: October 1, 2014
Last modified: October 25, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported