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Protein

Phospholipid-transporting ATPase

Gene

ATP11C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:ATP11CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101974.14.
HGNCiHGNC:13554. ATP11C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei290 – 313HelicalUniRule annotationAdd BLAST24
Transmembranei344 – 363HelicalUniRule annotationAdd BLAST20
Transmembranei903 – 923HelicalUniRule annotationAdd BLAST21
Transmembranei953 – 975HelicalUniRule annotationAdd BLAST23
Transmembranei987 – 1009HelicalUniRule annotationAdd BLAST23
Transmembranei1021 – 1044HelicalUniRule annotationAdd BLAST24
Transmembranei1064 – 1084HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101974.

PTM / Processingi

Proteomic databases

PaxDbiA0A067XG54.
PeptideAtlasiA0A067XG54.

Expressioni

Gene expression databases

BgeeiENSG00000101974.
ExpressionAtlasiA0A067XG54. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A067XG54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 91PhoLip_ATPase_NInterPro annotationAdd BLAST55
Domaini839 – 1087PhoLip_ATPase_CInterPro annotationAdd BLAST249

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili608 – 632Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00870000136387.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR030363. ATP11C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF133. PTHR24092:SF133. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A067XG54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRRSLNRFC AGEEKRVGTR TVFVGNHPVS ETEAYIAQRF CDNRIVSSKY
60 70 80 90 100
TLWNFLPKNL FEQFRRIANF YFLIIFLVQV TVDTPTSPVT SGLPLFFVIT
110 120 130 140 150
VTAIKQGYED CLRHRADNEV NKSTVYIIEN AKRVRKESEK IKVGDVVEVQ
160 170 180 190 200
ADETFPCDLI LLSSCTTDGT CYVTTASLDG ESNCKTHYAV RDTIALCTAE
210 220 230 240 250
SIDTLRAAIE CEQPQPDLYK FVGRINIYSN SLEAVARSLG PENLLLKGAT
260 270 280 290 300
LKNTEKIYGV AVYTGMETKM ALNYQGKSQK RSAVEKSINA FLIVYLFILL
310 320 330 340 350
TKAAVCTTLK YVWQSTPYND EPWYNQKTQK ERETLKVLKM FTDFLSFMVL
360 370 380 390 400
FNFIIPVSMY VTVEMQKFLG SFFISWDKDF YDEEINEGAL VNTSDLNEEL
410 420 430 440 450
GQVDYVFTDK TGTLTENSME FIECCIDGHK YKGVTQEVDG LSQTDGTLTY
460 470 480 490 500
FDKVDKNREE LFLRALCLCH TVEIKTNDAV DGATESAELT YISSSPDEIA
510 520 530 540 550
LVKGAKRYGF TFLGNRNGYM RVENQRKEIE EYELLHTLNF DAVRRRMSVI
560 570 580 590 600
VKTQEGDILL FCKGADSAVF PRVQNHEIEL TKVHVERNAM DGYRTLCVAF
610 620 630 640 650
KEIAPDDYER INRQLIEAKM ALQDREEKME KVFDDIETNM NLIGATAVED
660 670 680 690 700
KLQDQAAETI EALHAAGLKV WVLTGDKMET AKSTCYACRL FQTNTELLEL
710 720 730 740 750
TTKTIEESER KEDRLHELLI EYRKKLLHEF PKSTRSFKKA WTEHQEYGLI
760 770 780 790 800
IDGSTLSLIL NSSQDSSSNN YKSIFLQICM KCTAVLCCRM APLQKAQIVR
810 820 830 840 850
MVKNLKGSPI TLSIGDGAND VSMILESHVG IGKEGRQAAR NSDYSVPKFK
860 870 880 890 900
HLKKLLLAHG HLYYVRIAHL VQYFFYKNLC FILPQFLYQF FCGFSQQPLY
910 920 930 940 950
DAAYLTMYNI CFTSLPILAY SLLEQHINID TLTSDPRLYM KISGNAMLQL
960 970 980 990 1000
GPFLYWTFLA AFEGTVFFFG TYFLFQTASL EENGKVYGNW TFGTIVFTVL
1010 1020 1030 1040 1050
VFTVTLKLAL DTRFWTWINH FVIWGSLAFY VFFSFFWGGI IWPFLKQQRM
1060 1070 1080 1090 1100
YFVFAQMLSS VSTWLAIILL IFISLFPEIL LIVLKNVRRR SARNPNLELP
1110
MLLSYKHTDS GYS
Length:1,113
Mass (Da):127,681
Last modified:September 3, 2014 - v1
Checksum:iD4DC3D1ED1DFEF81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161777 Genomic DNA. No translation available.
AL356785 Genomic DNA. No translation available.
AL590077 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000370557; ENSP00000359588; ENSG00000101974.
UCSCiuc065bjm.1. human.

Similar proteinsi

Entry informationi

Entry nameiA0A067XG54_HUMAN
AccessioniPrimary (citable) accession number: A0A067XG54
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: September 27, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported