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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

sucB_1

Organism
Rickettsia buchneri
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:sucB_1Imported
ORF Names:REISMN_05845Imported
OrganismiRickettsia buchneriImported
Taxonomic identifieri1462938 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000027161 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliA0A067AJD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 78Lipoyl-bindingInterPro annotationAdd BLAST77
Domaini132 – 169Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili294 – 314Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, LipoylUniRule annotationSAAS annotation

Family and domain databases

Gene3Di4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR036625. E3-bd_dom_sf.
IPR006257. LAT1.
IPR004167. PSBD.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
PS51826. PSBD. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A067AJD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIKILMPAL SPTMTGGNLA RWLKKEGDKV NPGEVIVEIE TDKATMEVEA
60 70 80 90 100
VDEGILAKIV IPQNSQNVPV NSLIAVLSEE GEEKTDIDAF IAKNNSVSPL
110 120 130 140 150
PKTDTNLPKP HENIANVEEQ GAVIKHDTSK IFTSPLAKRL AKMGNIRLES
160 170 180 190 200
VKGSGPHGRI VKQDILSYTS STVHNKIVSR NPEEYRLVPN NNIRKIIAKR
210 220 230 240 250
LLESKQTVPH FYLSIECNVD KLLDIREDIN KSFSEDKSTK ISVNDFIILA
260 270 280 290 300
VAKALQEVPN ANASWGEDAI RYYNNVDISV AVAIENGLVT PIVKNANQKN
310 320 330 340 350
IIELSREMKE LIKKAKDNKL TPEEFQGGGF TISNLGMYGI KNFNAIINPP
360 370 380 390 400
QSCIMGVGSS SKRAIVKNDQ ITIATIMDVT LSADHRVVDG AAGAEFLAAF
410
KKFIESPALM LI
Length:412
Mass (Da):45,173
Last modified:September 3, 2014 - v1
Checksum:iAFF08DF166E757DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JFKF01000122 Genomic DNA. Translation: KDO02667.1.
RefSeqiWP_008580221.1. NZ_JFKF01000122.1.

Genome annotation databases

EnsemblBacteriaiKDO02667; KDO02667; REISMN_05845.

Similar proteinsi

Entry informationi

Entry nameiA0A067AJD2_9RICK
AccessioniPrimary (citable) accession number: A0A067AJD2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: December 20, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported