Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation, HelicaseImported, Hydrolase
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotationImported
Synonyms:uvrB_1Imported, uvrB_2Imported, uvrB_3Imported
ORF Names:AWW74_10375Imported, ERS019260_00707Imported, ERS019367_01221Imported, ERS019416_00440Imported, ERS019595_00798Imported, ERS020140_00174Imported, ERS020147_00328Imported, ERS020148_00290Imported, ERS020157_00135Imported, ERS020178_03752Imported, ERS020524_00269Imported, ERS020541_00072Imported, ERS020835_00402Imported, ERS021189_03816Imported, ERS021218_00529Imported, ERS021300_01825Imported, ERS021360_00307Imported, ERS021634_05386Imported, ERS021762_00047Imported, ERS022045_04735Imported, ERS022363_00296Imported, ERS022390_00246Imported, ERS043879_00913Imported, ERS232471_01604Imported, ERS232499_01087Imported, ERS367337_01939Imported, ERS409064_01233Imported, NTPn46_01315Imported, SAMEA1026345_00973Imported, SAMEA1026615_00803Imported, SAMEA2626804_00973Imported, SpnNT_01070Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000039962 Componenti: Unassembled WGS sequence
  • UP000045067 Componenti: Unassembled WGS sequence
  • UP000075530 Componenti: Unassembled WGS sequence
  • UP000198183 Componenti: Unassembled WGS sequence
  • UP000042505 Componenti: Unassembled WGS sequence
  • UP000044228 Componenti: Unassembled WGS sequence
  • UP000039440 Componenti: Unassembled WGS sequence
  • UP000043857 Componenti: Unassembled WGS sequence
  • UP000074995 Componenti: Unassembled WGS sequence
  • UP000046356 Componenti: Unassembled WGS sequence
  • UP000031393 Componenti: Chromosome
  • UP000046081 Componenti: Unassembled WGS sequence
  • UP000071227 Componenti: Unassembled WGS sequence
  • UP000070671 Componenti: Unassembled WGS sequence
  • UP000042781 Componenti: Unassembled WGS sequence
  • UP000044493 Componenti: Unassembled WGS sequence
  • UP000198094 Componenti: Unassembled WGS sequence
  • UP000045409 Componenti: Unassembled WGS sequence
  • UP000197616 Componenti: Unassembled WGS sequence
  • UP000044692 Componenti: Unassembled WGS sequence
  • UP000039362 Componenti: Unassembled WGS sequence
  • UP000043492 Componenti: Unassembled WGS sequence
  • UP000046095 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence
  • UP000044899 Componenti: Unassembled WGS sequence
  • UP000044836 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 188Helicase ATP-bindingInterPro annotationAdd BLAST158
Domaini435 – 601Helicase C-terminalInterPro annotationAdd BLAST167
Domaini626 – 661UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili622 – 649Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CCW. Bacteria.
COG0556. LUCA.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A064C029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINHITDNQF KLVSKYQPSG DQPQAIEQLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVISK VNKPTLVIAH NKTLAGQLYG EFKEFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYA DSVVSLRPGL EISRDKLLND LVDIQFERND IDFQRGRFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EVEALTGQVL GEVDHLAIFP
260 270 280 290 300
ATHFVTNDDH MEVAIAKIQA ELEEQLAVFE KEGKLLEAQR LKQRTEYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPDDFLI MIDESHMTIG
360 370 380 390 400
QIKGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYENEQTE TVIEQIIRPT GLLDPEVEVR PTMGQIDDLL GEINARVEKN
460 470 480 490 500
ERTFITTLTK KMAEDLTDYF KEMGIKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLVGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADT VTQSMQRAID ETARRRKIQM AYNEEHGIVP QTIKKEIRDL
610 620 630 640 650
IAVTKAVAKE EDKEVDINSL NKQERKELVK KLEKQMQEAV EVLDFELAAQ
660
IRDMMLEVKA LD
Length:662
Mass (Da):75,734
Last modified:September 3, 2014 - v1
Checksum:iC2EB617ED537BDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007593 Genomic DNA. Translation: AJD72009.1.
CFFK01000001 Genomic DNA. Translation: CEX78321.1.
CKCQ01000009 Genomic DNA. Translation: CIP97426.1.
CKJB01000003 Genomic DNA. Translation: CIT80466.1.
CKOI01000004 Genomic DNA. Translation: CIX00195.1.
CKRO01000014 Genomic DNA. Translation: CIZ03724.1.
CKTJ01000003 Genomic DNA. Translation: CIZ81409.1.
CLAY01000004 Genomic DNA. Translation: CJE89531.1.
CLBL01000027 Genomic DNA. Translation: CJF68922.1.
CLFU01000049 Genomic DNA. Translation: CJJ79047.1.
CLJU01000046 Genomic DNA. Translation: CJM06229.1.
CMAP01000002 Genomic DNA. Translation: CJV09751.1.
CMBJ01000006 Genomic DNA. Translation: CJV63805.1.
CMJQ01000001 Genomic DNA. Translation: CKA62733.1.
CMOR01000026 Genomic DNA. Translation: CKE28549.1.
CMQD01000015 Genomic DNA. Translation: CKE89273.1.
CQYR01000003 Genomic DNA. Translation: COB75768.1.
CQYS01000002 Genomic DNA. Translation: COB76199.1.
CQZC01000001 Genomic DNA. Translation: COB95398.1.
CQZO01000017 Genomic DNA. Translation: COD53196.1.
CRCK01000003 Genomic DNA. Translation: COE34720.1.
CRQU01000001 Genomic DNA. Translation: COO03498.1.
CRTN01000029 Genomic DNA. Translation: COR38720.1.
CRVC01000004 Genomic DNA. Translation: COR39860.1.
CNOG02000129 Genomic DNA. Translation: CTO25792.1.
FDEX01000008 Genomic DNA. Translation: CVT08300.1.
FEBA01000019 Genomic DNA. Translation: CWE86993.1.
LRSN01000134 Genomic DNA. Translation: KWX83099.1.
LJWP01000037 Genomic DNA. Translation: KXW43671.1.
FYLU01000006 Genomic DNA. Translation: SNG42316.1.
FYQS01000006 Genomic DNA. Translation: SNI81745.1.
FZBN01000008 Genomic DNA. Translation: SNO55474.1.
RefSeqiWP_000607027.1. NZ_NANX01000007.1.

Genome annotation databases

EnsemblBacteriaiAJD72009; AJD72009; SpnNT_01070.
CEW67834; CEW67834; ERS021528_00389.
CFP91348; CFP91348; ERS013931_00983.
CIP97426; CIP97426; ERS019260_00707.
CIT80466; CIT80466; ERS019595_00798.
CIX00195; CIX00195; ERS019416_00440.
CIZ03724; CIZ03724; ERS019367_01221.
CIZ81409; CIZ81409; ERS021360_00307.
CJE89531; CJE89531; ERS020835_00402.
CJF68922; CJF68922; ERS021300_01825.
CJJ79047; CJJ79047; ERS021634_05386.
CJK50723; CJK50723; ERS022016_01704.
CJM06229; CJM06229; ERS022045_04735.
CJV09751; CJV09751; ERS022390_00246.
CJV63805; CJV63805; ERS022363_00296.
CJY48501; CJY48501; ERS022329_01484.
CKA62733; CKA62733; ERS021762_00047.
CKE28549; CKE28549; ERS232471_01604.
CKE89273; CKE89273; ERS232499_01087.
CMX09837; CMX09837; ERS077238_01558.
CNA89347; CNA89347; ERS077235_01737.
CNB11305; CNB11305; ERS077244_01635.
CNY97600; CNY97600; ERS020873_00678.
COD53196; COD53196; ERS020178_03752.
COP37481; COP37481; EBG00005155609.
COR38720; COR38720; ERS021189_03816.
COR39860; COR39860; ERS021218_00529.
CTE04215; CTE04215; ERS044129_00912.
CTO25792; CTO25792; ERS043879_00913.
CVM60221; CVM60221; ERS367628_00852.
CVO65986; CVO65986; ERS367764_00217.
CVO89808; CVO89808; ERS408893_01785.
CVQ15436; CVQ15436; ERS515225_00617.
CVT08300; CVT08300; ERS409064_01233.
CVY82093; CVY82093; ERS409372_00798.
CWE86993; CWE86993; ERS367337_01939.
CWM26056; CWM26056; ERS515182_01406.
CYI54601; CYI54601; ERS394170_00264.
KWX83099; KWX83099; AWW74_10375.
KXW43671; KXW43671; NTPn46_01315.
PATRICifig|1313.5270.peg.10.

Similar proteinsi

Entry informationi

Entry nameiA0A064C029_STREE
AccessioniPrimary (citable) accession number: A0A064C029
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: November 22, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported