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Protein

Succinate--CoA ligase [ADP-forming] subunit beta

Gene

sucC

Organism
Comamonadaceae bacterium B1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.UniRule annotationSAAS annotation

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate--CoA ligase [ADP-forming] subunit beta (sucC), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPUniRule annotation1
Binding sitei99ATPUniRule annotation1
Binding sitei102ATP; via amide nitrogenUniRule annotation1
Binding sitei107ATPUniRule annotation1
Metal bindingi199MagnesiumUniRule annotation1
Metal bindingi213MagnesiumUniRule annotation1
Binding sitei264Substrate; shared with subunit alphaUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 55ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER00999

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate--CoA ligase [ADP-forming] subunit betaUniRule annotation (EC:6.2.1.5UniRule annotation)
Alternative name(s):
Succinyl-CoA synthetase subunit betaUniRule annotation
Short name:
SCS-betaUniRule annotation
Gene namesi
Name:sucCUniRule annotation
ORF Names:SMCB_1802Imported
OrganismiComamonadaceae bacterium B1Imported
Taxonomic identifieri1458426 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceae
Proteomesi
  • UP000066014 Componenti: Chromosome

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 229ATP-graspInterPro annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 323Substrate binding; shared with subunit alphaUniRule annotation3

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase beta subunit family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01903

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.50.261, 1 hit
HAMAPiMF_00558 Succ_CoA_beta, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013650 ATP-grasp_succ-CoA_synth-type
IPR013815 ATP_grasp_subdomain_1
IPR005811 CoA_ligase
IPR017866 Succ-CoA_synthase_bsu_CS
IPR005809 Succ_CoA_synthase_bsu
IPR016102 Succinyl-CoA_synth-like
PANTHERiPTHR11815 PTHR11815, 1 hit
PfamiView protein in Pfam
PF08442 ATP-grasp_2, 1 hit
PF00549 Ligase_CoA, 1 hit
PIRSFiPIRSF001554 SucCS_beta, 1 hit
SUPFAMiSSF52210 SSF52210, 1 hit
TIGRFAMsiTIGR01016 sucCoAbeta, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS01217 SUCCINYL_COA_LIG_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A060NRP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIHEYQAKD ILRQFGIPVP RGIPAFTVQE AVEAAQKLGG PVWVVKAQIH
60 70 80 90 100
AGGRGKGGGV KVAKSLDDLK ARASDILGMQ LVTHQTGPGG QKVRRLYIED
110 120 130 140 150
GADIQKEYYL SLVTDRGTQK VAFIASSEGG MDIEEVAHAT PEKIVKVFVD
160 170 180 190 200
PLVGLTPEQG AQLAQGIGMP AGSQAQFVEI CQNLYRCYME TDASLVEINP
210 220 230 240 250
LNRSSNGQLI ALDAKFNFDA NALFRHPEIV ALRDLDEEDP AEIEASKFDL
260 270 280 290 300
AYISLDGNIG CLVNGAGLAM STMDTIKLFG AEPANFLDVG GGATPEKVTE
310 320 330 340 350
AFKIMLKNDR VKAILVNIFG GIMKCDTIAT GVITACRAVN LSVPLVVRMK
360 370 380
GTNEELGKKM LAESGLPIIS ADTMAEAAQK VVAAVQA
Length:387
Mass (Da):41,295
Last modified:September 3, 2014 - v1
Checksum:i414E3FC60593F0CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP014569 Genomic DNA Translation: BAO84030.1
RefSeqiWP_045536415.1, NZ_AP014569.1

Genome annotation databases

EnsemblBacteriaiBAO84030; BAO84030; SMCB_1802
KEGGicbab:SMCB_1802

Similar proteinsi

Entry informationi

Entry nameiA0A060NRP4_9BURK
AccessioniPrimary (citable) accession number: A0A060NRP4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: June 20, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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