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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotationImported
Synonyms:argS_1Imported
ORF Names:B7R63_07025Imported, B9D92_07350Imported, BVW01_00300Imported, ERS007663_01494Imported, ERS007670_00638Imported, ERS007681_00050Imported, ERS007688_00795Imported, ERS023446_01608Imported, ERS024276_00016Imported, ERS027646_00454Imported, ERS027653_00429Imported, ERS027656_01309Imported, ERS124361_00754Imported, SAMEA2683035_01556Imported
OrganismiMycobacterium tuberculosisImported
Taxonomic identifieri1773 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000193898 Componenti: Unassembled WGS sequence
  • UP000197036 Componenti: Chromosome
  • UP000196705 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000049114 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 93Arg_tRNA_synt_NInterPro annotationAdd BLAST90
Domaini429 – 550DALR_1InterPro annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 140"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di3.30.1360.70. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR036695. Arg-tRNA-synth_N_sf.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A045J3G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPADLAELL KATAAAVLAE RGLDASALPQ MVTVERPRIP EHGDYASNLA
60 70 80 90 100
MQLAKKVGTN PRELAGWLAE ALTKVDGIAS AEVAGPGFIN MRLETAAQAK
110 120 130 140 150
VVTSVIDAGH SYGHSLLLAG RKVNLEFVSA NPTGPIHIGG TRWAAVGDAL
160 170 180 190 200
GRLLTTQGAD VVREYYFNDH GAQIDRFANS LIAAAKGEPT PQDGYAGSYI
210 220 230 240 250
TNIAEQVLQK APDALSLPDA ELRETFRAIG VDLMFDHIKQ SLHEFGTDFD
260 270 280 290 300
VYTHEDSMHT GGRVENAIAR LRETGNIYEK DGATWLRTSA FGDDKDRVVI
310 320 330 340 350
KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG
360 370 380 390 400
DDPATVEVLI GQMVNLVRDG QPVRMSKRAG TVLTLDDLVE AIGVDAARYS
410 420 430 440 450
LIRSSVDTAI DIDLALWSSA SNENPVYYVQ YAHARLSALA RNAAELALIP
460 470 480 490 500
DTNHLELLNH DKEGTLLRTL GEFPRVLETA ASLREPHRVC RYLEDLAGDY
510 520 530 540 550
HRFYDSCRVL PQGDEQPTDL HTARLALCQA TRQVIANGLA IIGVTAPERM
Length:550
Mass (Da):59,709
Last modified:July 9, 2014 - v1
Checksum:i4F11239A6238124D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP022014 Genomic DNA. Translation: ASD91649.1.
CFOE01000003 Genomic DNA. Translation: CFE34362.1.
CFOH01000083 Genomic DNA. Translation: CFE47581.1.
CNCN01000002 Genomic DNA. Translation: CKN63122.1.
CNFS01000056 Genomic DNA. Translation: CKQ97323.1.
CNFV01000164 Genomic DNA. Translation: CKR45333.1.
CNGE01000045 Genomic DNA. Translation: CKR69968.1.
CHDS01000007 Genomic DNA. Translation: CNG34748.1.
CQGE01000027 Genomic DNA. Translation: CNM91832.1.
CQPL01000084 Genomic DNA. Translation: CNT99297.1.
CQPV01000185 Genomic DNA. Translation: CNU59427.1.
NCTW01000001 Genomic DNA. Translation: OSC68976.1.
NDYV01000014 Genomic DNA. Translation: OWG30122.1.
FPTZ01000008 Genomic DNA. Translation: SGH59919.1.
RefSeqiWP_003406630.1. NZ_NCKT01000005.1.

Genome annotation databases

EnsemblBacteriaiAMC45658; AMC45658; RN05_1382.
CFE34362; CFE34362; ERS007681_00050.
CFE47581; CFE47581; ERS007688_00795.
CKN63122; CKN63122; ERS024276_00016.
CKQ97323; CKQ97323; ERS027653_00429.
CKR45333; CKR45333; ERS027656_01309.
CKR69968; CKR69968; ERS027646_00454.
CNG34748; CNG34748; ERS124361_00754.
CNM91832; CNM91832; ERS023446_01608.
CNT99297; CNT99297; ERS007670_00638.
CNU59427; CNU59427; ERS007663_01494.
CNY20383; CNY20383; ERS013471_00796.
CRH14153; CRH14153; BN1303_02503.
CRH16247; CRH16247; BN1213_03712.
PATRICifig|1773.211.peg.651.

Similar proteinsi

Entry informationi

Entry nameiA0A045J3G9_MYCTX
AccessioniPrimary (citable) accession number: A0A045J3G9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported