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Protein

Thymidine kinase

Gene

tdk

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:A8C65_06995Imported, A9R57_00175Imported, ACU57_17605Imported, AM266_12505Imported, AM341_02240Imported, AUQ13_16185Imported, BET08_38460Imported, BHS87_06500Imported, BJJ90_10870Imported, BUE81_18965Imported, BZL31_06495Imported, CA593_21685Imported, CR534_14675Imported, CTI76_25370Imported, EC3234A_230c00230Imported, EL75_2529Imported, EL79_2534Imported, EL80_2535Imported, ERS085365_01740Imported, ERS085416_00023Imported, ERS139211_03179Imported, ERS150873_03089Imported, SK85_01372Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000051850 Componenti: Unassembled WGS sequence
  • UP000230960 Componenti: Chromosome
  • UP000229255 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000188465 Componenti: Unassembled WGS sequence
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000194908 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000196822 Componenti: Unassembled WGS sequence
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000070045 Componenti: Unassembled WGS sequence
  • UP000234324 Componenti: Chromosome
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000194199 Componenti: Chromosome
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000042305 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000185422 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A037Y488-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTVVYTAEI DDRFGAGKVS
60 70 80 90 100
SRIGLSSPAK LFNQNSSLFD EIRAEHEQQA IHCVLVDECQ FLTRQQVYEL
110 120 130 140 150
SEVVDQLDIP VLCYGLRTDF RGELFIGSQY LLAWSDKLVE LKTICFCGRK
160 170 180 190 200
ASMVLRLDQA GRPYNEGEQV VIGGNERYVS VCRKHYKEAL QVDSLTAIQE

RHRHD
Length:205
Mass (Da):23,457
Last modified:July 9, 2014 - v1
Checksum:i533166D9EAD20E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA. Translation: APT02479.1.
CP021175 Genomic DNA. Translation: ARR35502.1.
CP024859 Genomic DNA. Translation: ATX50720.1.
CP024127 Genomic DNA. Translation: AUK22253.1.
CYAQ01000012 Genomic DNA. Translation: CTS45052.1.
CYCX01000001 Genomic DNA. Translation: CTU79587.1.
CYDH01000033 Genomic DNA. Translation: CTW42117.1.
CYFX01000021 Genomic DNA. Translation: CTZ58921.1.
JPKH01000037 Genomic DNA. Translation: KGM69110.1.
JPKL01000088 Genomic DNA. Translation: KGM78640.1.
JPMZ01000040 Genomic DNA. Translation: KGM81550.1.
LEUM01000009 Genomic DNA. Translation: KLX99583.1.
LDYI01000118 Genomic DNA. Translation: KPO09370.1.
LIVE01000018 Genomic DNA. Translation: KQJ15284.1.
LOOZ01000023 Genomic DNA. Translation: KXR89365.1.
LCVH01000230 Genomic DNA. Translation: OAC28457.1.
LZEH01000112 Genomic DNA. Translation: OEI65362.1.
MSEK01000134 Genomic DNA. Translation: OLR85735.1.
MCNL01001098 Genomic DNA. Translation: ONK53052.1.
NAFT01000024 Genomic DNA. Translation: ORT08011.1.
MUAB01000009 Genomic DNA. Translation: OUK53234.1.
LYBG01000474 Genomic DNA. Translation: OWD72843.1.
PEQI01000173 Genomic DNA. Translation: PIM55412.1.
RefSeqiWP_000068077.1. NZ_PJIY01000003.1.

Genome annotation databases

EnsemblBacteriaiCTS45052; CTS45052; ERS085365_01740.
CTU79587; CTU79587; ERS085416_00023.
CTW42117; CTW42117; ERS139211_03179.
CTZ58921; CTZ58921; ERS150873_03089.
KGM69110; KGM69110; EL75_2529.
KGM78640; KGM78640; EL80_2535.
KGM81550; KGM81550; EL79_2534.
KIG79683; KIG79683; PU38_17130.
KLX99583; KLX99583; SK85_01372.
KPO09370; KPO09370; ACU57_17605.
KQJ15284; KQJ15284; AM266_12505.
KXQ40387; KXQ40387; AUQ01_08825.
OAC28457; OAC28457; EC3234A_230c00230.
OCO53015; OCO53015; AN669_0215565.
ODH30841; ODH30841; A6803_09195.
OEI65362; OEI65362; A9R57_00175.
PATRICifig|562.10493.peg.1328.

Similar proteinsi

Entry informationi

Entry nameiA0A037Y488_ECOLX
AccessioniPrimary (citable) accession number: A0A037Y488
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported