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Protein

Transcription antitermination protein RfaH

Gene

rfaH

Organism
Escherichia coli O111:NM str. K6722
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription antiterminationUniRule annotationSAAS annotation, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription antitermination protein RfaHUniRule annotation
Gene namesi
Name:rfaHUniRule annotationImported
ORF Names:BY96_23590Imported
OrganismiEscherichia coli O111:NM str. K6722Imported
Taxonomic identifieri1446533 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000024307 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A027TGE8.
SMRiA0A027TGE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 100NGNInterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the RfaH family.UniRule annotation

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.30.70.940. 1 hit.
HAMAPiMF_00951. RfaH. 1 hit.
InterProiView protein in InterPro
IPR006645. NGN_dom.
IPR036735. NGN_dom_sf.
IPR014722. Rib_L2_dom2.
IPR010215. Transcription_antiterm_RfaH.
PfamiView protein in Pfam
PF02357. NusG. 1 hit.
SMARTiView protein in SMART
SM00738. NGN. 1 hit.
SUPFAMiSSF82679. SSF82679. 1 hit.
TIGRFAMsiTIGR01955. RfaH. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A027TGE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSWYLLYCK RGQLQRAQEH LERQAVNCLA PMITLEKIVR GKRTAVSEPL
60 70 80 90 100
FPNYLFVEFD PEVIHTTTIN ATRGVSHFVR FGASPAIVPS AVIHQLSVYK
110 120 130 140 150
PKDIVDPATP YPGDKVIITE GAFEGFQAIF TEPDGEARSM LLLNLINKEI
160
KHSVKNTEFR KL
Length:162
Mass (Da):18,340
Last modified:July 9, 2014 - v1
Checksum:i2A298947EBB58C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JHHU01000071 Genomic DNA. Translation: EZD24456.1.
RefSeqiWP_001192396.1. NZ_JHHU01000071.1.

Genome annotation databases

EnsemblBacteriaiEZD24456; EZD24456; BY96_23590.

Similar proteinsi

Entry informationi

Entry nameiA0A027TGE8_ECOLX
AccessioniPrimary (citable) accession number: A0A027TGE8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 25, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported