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Protein

Odorant receptor coreceptor

Gene

Orco

Organism
Ooceraea biroi (Clonal raider ant) (Cerapachys biroi)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Odorant coreceptor which complexes with conventional odorant receptors (ORs) to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity). Obligate coreceptor of all odorant receptors (By similarity). Orco is a universal and integral part of the functional odorant receptor, involved in the dendritic localization of other olfactory receptors. Can form functional ion channels in the absence of an odor-binding odorant receptor (By similarity). Plays a central role in the perception of olfactory stimuli in ants and is essential for ant social organization (PubMed:28802042). Required for pheromone sensing (PubMed:28802042). Also required for the development and maintenance of odorant receptor neurons (ORNs) and of antennal lobe glomeruli (PubMed:28802042).By similarity1 Publication

Miscellaneous

In contrast to other ant species, C.biroi ants reproduce via parthenogenesis, enabling stable germline modifications from the clonal progeny of injected individuals without laboratory crosses.1 Publication

GO - Molecular functioni

  • odorant binding Source: InterPro
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • antennal development Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception of smell Source: UniProtKB
  • detection of pheromone Source: UniProtKB
  • olfactory behavior Source: UniProtKB
  • response to pheromone Source: UniProtKB
  • social behavior Source: UniProtKB

Keywordsi

Molecular functionReceptor, Transducer
Biological processBehavior, Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor coreceptorUniRule annotation
Gene namesi
Name:Orco1 Publication
ORF Names:X777_12371Imported
OrganismiOoceraea biroi (Clonal raider ant) (Cerapachys biroi)
Taxonomic identifieri2015173 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataVespoideaFormicidaeDorylinaeOoceraea
Proteomesi
  • UP000053097 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicCuratedAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 73ExtracellularCurated9
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 133CytoplasmicCuratedAdd BLAST39
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini155 – 190ExtracellularCuratedAdd BLAST36
Transmembranei191 – 211Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini212 – 349CytoplasmicCuratedAdd BLAST138
Transmembranei350 – 370Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini371 – 382ExtracellularCuratedAdd BLAST12
Transmembranei383 – 403Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini404 – 454CytoplasmicCuratedAdd BLAST51
Transmembranei455 – 475Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini476 – 478ExtracellularCurated3

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impaired behavior and fitness, probably due to loss of pheromone sensing. Ants also display gross neuroanatomical defects in the antennal lobe, with a dramatic decrease in the number of antennal lobe glomeruli.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004420031 – 478Odorant receptor coreceptorAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi167N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Present in antennae (at protein level).1 Publication

Interactioni

Subunit structurei

Heterodimer with conventional odorant receptors (ORs).By similarity

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OMAiQIYYVLF.

Family and domain databases

InterProiView protein in InterPro
IPR004117. 7tm6_olfct_rcpt.
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiView protein in Pfam
PF02949. 7tm_6. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A026W182-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKMKQQGLV ADLLPNIRVM KTFGHFVFNY YNDNSSKYLH KVYCCVNLFM
60 70 80 90 100
LLLQFGLCAV NLIVESADVD DLTANTITLL FFTHSIVKIC YFAIRSKYFY
110 120 130 140 150
RTWAIWNNPN SHPLFAESNA RYHAIALKKM RLLLFLVGGT TMLAAVAWTV
160 170 180 190 200
LTFFEHPIRK IVDPVTNETE IIELPQLLIR SFYPFDAGKG ITHVLVLVYQ
210 220 230 240 250
FYWVLFMLID ANSLDVLFCS WLLFACEQLQ HLKQIMKPLM ELSATLDTVV
260 270 280 290 300
PNSSELFKAG SADHLRDGDN PPPPPPPQSD NMLDLDLRNI YSNRQDFTAT
310 320 330 340 350
FRPTAGMTFN GGVGPNGLTK KQEALVRSAI KYWVERHKHI VRLVTAVGDA
360 370 380 390 400
YGFALLLHML TTTITLTLLA YQATKVNGIN VYAASTIGYI LYTFGQVFLF
410 420 430 440 450
CIFGNRLIEE STSVMEAAYS CHWYDGSEEA KTFVQIVCQQ CQKAMSISGA
460 470
KFFTVSLDLF ASVLGAVVTY FMVLVQLK
Length:478
Mass (Da):54,109
Last modified:July 9, 2014 - v1
Checksum:iC35E3F2B46573CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KK107522 Genomic DNA. Translation: EZA49341.1.

Similar proteinsi

Entry informationi

Entry nameiORCO_OOCBI
AccessioniPrimary (citable) accession number: A0A026W182
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families