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Protein

General transcription factor IIF subunit 2

Gene

GTF2F2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, HelicaseUniRule annotation, Hydrolase
Biological processTranscription, Transcription regulationUniRule annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIF subunit 2UniRule annotation (EC:3.6.4.12UniRule annotation)
Alternative name(s):
Transcription initiation factor IIF subunit betaUniRule annotation
Gene namesi
Name:GTF2F2Imported
ORF Names:hCG_1811827Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000188342.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiA0A024RDU9.
PRIDEiA0A024RDU9.

Expressioni

Gene expression databases

BgeeiENSG00000188342.
ExpressionAtlasiA0A024RDU9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A024RDU9.
SMRiA0A024RDU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIF beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2905. Eukaryota.
COG5090. LUCA.
KOiK03139.
OMAiNMWELKK.
OrthoDBiEOG091G0IN2.
PhylomeDBiA0A024RDU9.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR003196. TFIIF_beta.
IPR011039. TFIIF_interaction.
IPR036388. WH-like_DNA-bd_sf.
IPR036390. WH_DNA-bd_sf.
PANTHERiPTHR10445. PTHR10445. 1 hit.
PfamiView protein in Pfam
PF02270. TFIIF_beta. 1 hit.
PIRSFiPIRSF015849. TFIIF-beta. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF50916. SSF50916. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024RDU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERGELDLT GAKQNTGVWL VKVPKYLSQQ WAKASGRGEV GKLRIAKTQG
60 70 80 90 100
RTEVSFTLNE DLANIHDIGG KPASVSAPRE HPFVLQSVGG QTLTVFTESS
110 120 130 140 150
SDKLSLEGIV VQRAECRPAA SENYMRLKRL QIEESSKPVR LSQQLDKVVT
160 170 180 190 200
TNYKPVANHQ YNIEYERKKK EDGKRARADK QHVLDMLFSA FEKHQYYNLK
210 220 230 240
DLVDITKQPV VYLKEILKEI GVQNVKGIHK NTWELKPEYR HYQGEEKSD
Length:249
Mass (Da):28,380
Last modified:July 9, 2014 - v1
Checksum:i05A1A9F8D31B749C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA. Translation: EAX08729.1.
RefSeqiNP_004119.1. NM_004128.2.
UniGeneiHs.654582.

Genome annotation databases

GeneIDi2963.
KEGGihsa:2963.

Similar proteinsi

Entry informationi

Entry nameiA0A024RDU9_HUMAN
AccessioniPrimary (citable) accession number: A0A024RDU9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 25, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.