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Protein
Submitted name:

High-mobility group box 1, isoform CRA_a

Gene

HMGB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 79HMG boxPROSITE-ProRule annotationAdd BLAST71
DNA bindingi95 – 163HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
High-mobility group box 1, isoform CRA_aImported
Gene namesi
Name:HMGB1Imported
ORF Names:hCG_2020366Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000189403.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA0A024RDR0

Expressioni

Gene expression databases

BgeeiENSG00000189403
ExpressionAtlasiA0A024RDR0 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A024RDR0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 79HMG boxInterPro annotationAdd BLAST71
Domaini95 – 163HMG boxInterPro annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 165Sequence analysisAdd BLAST21
Coiled coili175 – 211Sequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
KOiK10802
OMAiYSQDKRP
OrthoDBiEOG091G0P81

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR017967 HMG_boxA_CS
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF09011 HMG_box_2, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SUPFAMiSSF47095 SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS00353 HMG_BOX_1, 1 hit
PS50118 HMG_BOX_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A024RDR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK
60 70 80 90 100
TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS
110 120 130 140 150
AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK
160 170 180 190 200
LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE
210
EDEEDEDEEE DDDDE
Length:215
Mass (Da):24,894
Last modified:July 9, 2014 - v1
Checksum:i8A868CF277D417B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA Translation: EAX08459.1
CH471075 Genomic DNA Translation: EAX08460.1
CH471075 Genomic DNA Translation: EAX08461.1
CH471075 Genomic DNA Translation: EAX08462.1
RefSeqiNP_001300821.1, NM_001313892.1
NP_001300822.1, NM_001313893.1
NP_002119.1, NM_002128.5
UniGeneiHs.434102
Hs.593339
Hs.596078

Genome annotation databases

GeneIDi3146
KEGGihsa:3146

Similar proteinsi

Entry informationi

Entry nameiA0A024RDR0_HUMAN
AccessioniPrimary (citable) accession number: A0A024RDR0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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