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Protein
Submitted name:

High-mobility group box 1, isoform CRA_a

Gene

HMGB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi9 – 79HMG boxPROSITE-ProRule annotationAdd BLAST71
DNA bindingi95 – 163HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
High-mobility group box 1, isoform CRA_aImported
Gene namesi
Name:HMGB1Imported
ORF Names:hCG_2020366Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Expressioni

Gene expression databases

ExpressionAtlasiA0A024RDR0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000343040.

Structurei

3D structure databases

SMRiA0A024RDR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 79HMG box DNA-bindingInterPro annotationAdd BLAST71
Domaini95 – 163HMG box DNA-bindingInterPro annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 211Sequence analysisAdd BLAST37

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
KOiK10802.
OMAiAFFFYSQ.
OrthoDBiEOG091G0P81.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 2 hits.
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiView protein in PROSITE
PS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.

Sequencei

Sequence statusi: Complete.

A0A024RDR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK
60 70 80 90 100
TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS
110 120 130 140 150
AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK
160 170 180 190 200
LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE
210
EDEEDEDEEE DDDDE
Length:215
Mass (Da):24,894
Last modified:July 9, 2014 - v1
Checksum:i8A868CF277D417B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA. Translation: EAX08459.1.
CH471075 Genomic DNA. Translation: EAX08460.1.
CH471075 Genomic DNA. Translation: EAX08461.1.
CH471075 Genomic DNA. Translation: EAX08462.1.
RefSeqiNP_001300821.1. NM_001313892.1.
NP_001300822.1. NM_001313893.1.
NP_002119.1. NM_002128.5.
UniGeneiHs.434102.
Hs.593339.
Hs.596078.

Genome annotation databases

GeneIDi3146.
KEGGihsa:3146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA. Translation: EAX08459.1.
CH471075 Genomic DNA. Translation: EAX08460.1.
CH471075 Genomic DNA. Translation: EAX08461.1.
CH471075 Genomic DNA. Translation: EAX08462.1.
RefSeqiNP_001300821.1. NM_001313892.1.
NP_001300822.1. NM_001313893.1.
NP_002119.1. NM_002128.5.
UniGeneiHs.434102.
Hs.593339.
Hs.596078.

3D structure databases

SMRiA0A024RDR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000343040.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3146.
KEGGihsa:3146.

Organism-specific databases

CTDi3146.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
KOiK10802.
OMAiAFFFYSQ.
OrthoDBiEOG091G0P81.

Miscellaneous databases

GenomeRNAii3146.

Gene expression databases

ExpressionAtlasiA0A024RDR0. baseline and differential.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR017967. HMG_boxA_CS.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 2 hits.
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiView protein in PROSITE
PS00353. HMG_BOX_1. 1 hit.
PS50118. HMG_BOX_2. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024RDR0_HUMAN
AccessioniPrimary (citable) accession number: A0A024RDR0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: March 15, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.