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Protein

Kit ligand

Gene

KITLG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Kit ligandUniRule annotation
Alternative name(s):
c-Kit ligandUniRule annotation
Gene namesi
Name:KITLGImported
ORF Names:hCG_26603Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 209HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500153665426 – 245Kit ligandSequence analysisAdd BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 163UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PRIDEiA0A024RBF5.

Expressioni

Gene expression databases

ExpressionAtlasiA0A024RBF5. baseline and differential.

Interactioni

Subunit structurei

Homodimer, non-covalently linked.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024RBF5.
SMRiA0A024RBF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCF family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003452. SCF.
PANTHERiPTHR11574. PTHR11574. 1 hit.
PfamiView protein in Pfam
PF02404. SCF. 2 hits.
PIRSFiPIRSF015599. SCF. 2 hits.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024RBF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD
60 70 80 90 100
YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI
110 120 130 140 150
IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA
160 170 180 190 200
FKDFVVASET SDCVVSSTLS PEKGKAKNPP GDSSLHWAAM ALPALFSLII
210 220 230 240
GFAFGALYWK KRQPSLTRAV ENIQINEEDN EISMLQEKER EFQEV
Length:245
Mass (Da):27,867
Last modified:July 9, 2014 - v1
Checksum:i937AEA64456DF4FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471054 Genomic DNA. Translation: EAW97419.1.
RefSeqiNP_003985.2. NM_003994.5.
UniGeneiHs.1048.
Hs.661108.

Genome annotation databases

GeneIDi4254.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiA0A024RBF5_HUMAN
AccessioniPrimary (citable) accession number: A0A024RBF5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: July 5, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.