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Protein
Submitted name:

Synaptotagmin I, isoform CRA_a

Gene

SYT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Synaptotagmin I, isoform CRA_aImported
Gene namesi
Name:SYT1Imported
ORF Names:hCG_2016754Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000067715.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei59 – 80HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA0A024RBE9.
PRIDEiA0A024RBE9.

Expressioni

Gene expression databases

BgeeiENSG00000067715.
ExpressionAtlasiA0A024RBE9. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024RBE9.
SMRiA0A024RBE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 245C2InterPro annotationAdd BLAST89
Domaini287 – 378C2InterPro annotationAdd BLAST92

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IT3Q. Eukaryota.
ENOG410Z15P. LUCA.
KOiK15290.
OMAiHNATEPA.
OrthoDBiEOG091G0XMQ.
PhylomeDBiA0A024RBE9.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR001565. Synaptotagmin.
IPR015428. Synaptotagmin1/2.
PANTHERiPTHR10024:SF239. PTHR10024:SF239. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 2 hits.

Sequencei

Sequence statusi: Complete.

A0A024RBE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE
60 70 80 90 100
LHKIPLPPWA LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN
110 120 130 140 150
AINMKDVKDL GKTMKDQALK DDDAETGLTD GEEKEEPKEE EKLGKLQYSL
160 170 180 190 200
DYDFQNNQLL VGIIQAAELP ALDMGGTSDP YVKVFLLPDK KKKFETKVHR
210 220 230 240 250
KTLNPVFNEQ FTFKVPYSEL GGKTLVMAVY DFDRFSKHDI IGEFKVPMNT
260 270 280 290 300
VDFGHVTEEW RDLQSAEKEE QEKLGDICFS LRYVPTAGKL TVVILEAKNL
310 320 330 340 350
KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT IKKNTLNPYY NESFSFEVPF
360 370 380 390 400
EQIQKVQVVV TVLDYDKIGK NDAIGKVFVG YNSTGAELRH WSDMLANPRR
410 420
PIAQWHTLQV EEEVDAMLAV KK
Length:422
Mass (Da):47,573
Last modified:July 9, 2014 - v1
Checksum:i467F7C58E411AFA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471054 Genomic DNA. Translation: EAW97344.1.
RefSeqiNP_001129277.1. NM_001135805.1.
NP_001129278.1. NM_001135806.1.
NP_005630.1. NM_005639.2.
XP_011537012.1. XM_011538710.1.
XP_016875398.1. XM_017019909.1.
UniGeneiHs.310545.

Genome annotation databases

GeneIDi6857.
KEGGihsa:6857.

Similar proteinsi

Entry informationi

Entry nameiA0A024RBE9_HUMAN
AccessioniPrimary (citable) accession number: A0A024RBE9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 25, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.