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Protein

Kit ligand

Gene

KITLG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Kit ligandUniRule annotation
Alternative name(s):
c-Kit ligandUniRule annotation
Gene namesi
Name:KITLGImported
ORF Names:hCG_26603Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000049130.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei213 – 237HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501102462126 – 273Kit ligandSequence analysisAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 114UniRule annotation
Disulfide bondi68 ↔ 163UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000049130.

Interactioni

Subunit structurei

Homodimer, non-covalently linked.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A024RBC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SCF family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF3Y. Eukaryota.
ENOG410XYQR. LUCA.
KOiK05461.
OMAiVKTKGIC.
OrthoDBiEOG091G0I23.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003452. SCF.
PANTHERiPTHR11574. PTHR11574. 1 hit.
PfamiView protein in Pfam
PF02404. SCF. 1 hit.
PIRSFiPIRSF015599. SCF. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024RBC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD
60 70 80 90 100
YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI
110 120 130 140 150
IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA
160 170 180 190 200
FKDFVVASET SDCVVSSTLS PEKDSRVSVT KPFMLPPVAA SSLRNDSSSS
210 220 230 240 250
NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR QPSLTRAVEN
260 270
IQINEEDNEI SMLQEKEREF QEV
Length:273
Mass (Da):30,899
Last modified:July 9, 2014 - v1
Checksum:i19FD362CB59C6607
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471054 Genomic DNA. Translation: EAW97416.1.
CH471054 Genomic DNA. Translation: EAW97418.1.
RefSeqiNP_000890.1. NM_000899.4.
UniGeneiHs.1048.
Hs.661108.

Genome annotation databases

GeneIDi4254.
KEGGihsa:4254.

Similar proteinsi

Entry informationi

Entry nameiA0A024RBC0_HUMAN
AccessioniPrimary (citable) accession number: A0A024RBC0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.