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Protein
Submitted name:

Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_c

Gene

CSPG2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_cImported
Gene namesi
Name:CSPG2Imported
ORF Names:hCG_2015974Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000038427.15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501001078321 – 2409Sequence analysisAdd BLAST2389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi196 ↔ 217PROSITE-ProRule annotation
Disulfide bondi294 ↔ 315PROSITE-ProRule annotation
Disulfide bondi2128 ↔ 2137PROSITE-ProRule annotation
Disulfide bondi2166 ↔ 2175PROSITE-ProRule annotation
Disulfide bondi2309 ↔ 2352PROSITE-ProRule annotation
Disulfide bondi2338 ↔ 2365PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000038427.
ExpressionAtlasiA0A024RAL1. baseline and differential.

Structurei

3D structure databases

SMRiA0A024RAL1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 146Ig-likeInterPro annotationAdd BLAST113
Domaini150 – 245LinkInterPro annotationAdd BLAST96
Domaini251 – 347LinkInterPro annotationAdd BLAST97
Domaini2102 – 2138EGF-likeInterPro annotationAdd BLAST37
Domaini2140 – 2176EGF-likeInterPro annotationAdd BLAST37
Domaini2189 – 2303C-type lectinInterPro annotationAdd BLAST115
Domaini2307 – 2367SushiInterPro annotationAdd BLAST61

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IFXS. Eukaryota.
ENOG410ZPDG. LUCA.

Family and domain databases

CDDicd00033. CCP. 1 hit.
cd03588. CLECT_CSPGs. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR018378. C-type_lectin_CS.
IPR033987. CSPG_CTLD.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
IPR035976. Sushi/SCR/CCP_sf.
IPR000436. Sushi_SCR_CCP_dom.
PfamiView protein in Pfam
PF00008. EGF. 2 hits.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
PRINTSiPR01265. LINKMODULE.
SMARTiView protein in SMART
SM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 1 hit.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024RAL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFINIKSILW MCSTLIVTHA LHKVKVGKSP PVRGSLSGKV SLPCHFSTMP
60 70 80 90 100
TLPPSYNTSE FLRIKWSKIE VDKNGKDLKE TTVLVAQNGN IKIGQDYKGR
110 120 130 140 150
VSVPTHPEAV GDASLTVVKL LASDAGLYRC DVMYGIEDTQ DTVSLTVDGV
160 170 180 190 200
VFHYRAATSR YTLNFEAAQK ACLDVGAVIA TPEQLFAAYE DGFEQCDAGW
210 220 230 240 250
LADQTVRYPI RAPRVGCYGD KMGKAGVRTY GFRSPQETYD VYCYVDHLDG
260 270 280 290 300
DVFHLTVPSK FTFEEAAKEC ENQDARLATV GELQAAWRNG FDQCDYGWLS
310 320 330 340 350
DASVRHPVTV ARAQCGGGLL GVRTLYRFEN QTGFPPPDSR FDAYCFKRRM
360 370 380 390 400
SDLSVIGHPI DSESKEDEPC SEETDPVHDL MAEILPEFPD IIEIDLYHSE
410 420 430 440 450
ENEEEEEECA NATDVTTTPS VQYINGKHLV TTVPKDPEAA EARRGQFESV
460 470 480 490 500
APSQNFSDSS ESDTHPFVIA KTELSTAVQP NESTETTESL EVTWKPETYP
510 520 530 540 550
ETSEHFSGGE PDVFPTVPFH EEFESGTAKK GAESVTERDT EVGHQAHEHT
560 570 580 590 600
EPVSLFPEES SGEIAIDQES QKIAFARATE VTFGEEVEKS TSVTYTPTIV
610 620 630 640 650
PSSASAYVSE EEAVTLIGNP WPDDLLSTKE SWVEATPRQV VELSGSSSIP
660 670 680 690 700
ITEGSGEAEE DEDTMFTMVT DLSQRNTTDT LITLDTSRII TESFFEVPAT
710 720 730 740 750
TIYPVSEQPS AKVVPTKFVS ETDTSEWISS TTVEEKKRKE EEGTTGTAST
760 770 780 790 800
FEVYSSTQRS DQLILPFELE SPNVATSSDS GTRKSFMSLT TPTQSEREMT
810 820 830 840 850
DSTPVFTETN TLENLGAQTT EHSSIHQPGV QEGLTTLPRS PASVFMEQGS
860 870 880 890 900
GEAAADPETT TVSSFSLNVE YAIQAEKEVA GTLSPHVETT FSTEPTGLVL
910 920 930 940 950
STVMDRVVAE NITQTSREIV ISERLGEPNY GAEIRGFSTG FPLEEDFSGD
960 970 980 990 1000
FREYSTVSHP IAKEETVMME GSGDAAFRDT QTSPSTVPTS VHISHISDSE
1010 1020 1030 1040 1050
GPSSTMVSTS AFPWEEFTSS AEGSGEQLVT VSSSVVPVLP SAVQKFSGTA
1060 1070 1080 1090 1100
SSIIDEGLGE VGTVNEIDRR STILPTAEVE GTKAPVEKEE VKVSGTVSTN
1110 1120 1130 1140 1150
FPQTIEPAKL WSRQEVNPVR QEIESETTSE EQIQEEKSFE SPQNSPATEQ
1160 1170 1180 1190 1200
TIFDSQTFTE TELKTTDYSV LTTKKTYSDD KEMKEEDTSL VNMSTPDPDA
1210 1220 1230 1240 1250
NGLESYTTLP EATEKSHFFL ATALVTESIP AEHVVTDSPI KKEESTKHFP
1260 1270 1280 1290 1300
KGMRPTIQES DTELLFSGLG SGEEVLPTLP TESVNFTEVE QINNTLYPHT
1310 1320 1330 1340 1350
SQVESTSSDK IEDFNRMENV AKEVGPLVSQ TDIFEGSGSV TSTTLIEILS
1360 1370 1380 1390 1400
DTGAEGPTVA PLPFSTDIGH PQNQTVRWAE EIQTSRPQTI TEQDSNKNSS
1410 1420 1430 1440 1450
TAEINETTTS STDFLARAYG FEMAKEFVTS APKPSDLYYE PSGEGSGEVD
1460 1470 1480 1490 1500
IVDSFHTSAT TQATRQESST TFVSDGSLEK HPEVPSAKAV TADGFPTVSV
1510 1520 1530 1540 1550
MLPLHSEQNK SSPDPTSTLS NTVSYERSTD GSFQDRFREF EDSTLKPNRK
1560 1570 1580 1590 1600
KPTENIIIDL DKEDKDLILT ITESTILEIL PELTSDKNTI IDIDHTKPVY
1610 1620 1630 1640 1650
EDILGMQTDI DTEVPSEPHD SNDESNDDST QVQEIYEAAV NLSLTEETFE
1660 1670 1680 1690 1700
GSADVLASYT QATHDESMTY EDRSQLDHMG FHFTTGIPAP STETELDVLL
1710 1720 1730 1740 1750
PTATSLPIPR KSATVIPEIE GIKAEAKALD DMFESSTLSD GQAIADQSEI
1760 1770 1780 1790 1800
IPTLGQFERT QEEYEDKKHA GPSFQPEFSS GAEEALVDHT PYLSIATTHL
1810 1820 1830 1840 1850
MDQSVTEVPD VMEGSNPPYY TDTTLAVSTF AKLSSQTPSS PLTIYSGSEA
1860 1870 1880 1890 1900
SGHTEIPQPS ALPGIDVGSS VMSPQDSFKE IHVNIEATFK PSSEEYLHIT
1910 1920 1930 1940 1950
EPPSLSPDTK LEPSEDDGKP ELLEEMEASP TELIAVEGTE ILQDFQNKTD
1960 1970 1980 1990 2000
GQVSGEAIKM FPTIKTPEAG TVITTADEIE LEGATQWPHS TSASATYGVE
2010 2020 2030 2040 2050
AGVVPWLSPQ TSERPTLSSS PEINPETQAA LIRGQDSTIA ASEQQVAARI
2060 2070 2080 2090 2100
LDSNDQATVN PVEFNTEVAT PPFSLLETSN ETDFLIGINE ESVEGTAIYL
2110 2120 2130 2140 2150
PGPDRCKMNP CLNGGTCYPT ETSYVCTCVP GYSGDQCELD FDECHSNPCR
2160 2170 2180 2190 2200
NGATCVDGFN TFRCLCLPSY VGALCEQDTE TCDYGWHKFQ GQCYKYFAHR
2210 2220 2230 2240 2250
RTWDAAEREC RLQGAHLTSI LSHEEQMFVN RVGHDYQWIG LNDKMFEHDF
2260 2270 2280 2290 2300
RWTDGSTLQY ENWRPNQPDS FFSAGEDCVV IIWHENGQWN DVPCNYHLTY
2310 2320 2330 2340 2350
TCKKGTVACG QPPVVENAKT FGKMKPRYEI NSLIRYHCKD GFIQRHLPTI
2360 2370 2380 2390 2400
RCLGNGRWAI PKITCMNPSA YQRTYSMKYF KNSSSAKDNS INTSKHDHRW

SRRWQESRR
Length:2,409
Mass (Da):265,050
Last modified:July 9, 2014 - v1
Checksum:i4D290F9BF5A3F704
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471084 Genomic DNA. Translation: EAW95906.1.
CH471084 Genomic DNA. Translation: EAW95907.1.
RefSeqiNP_001157569.1. NM_001164097.1.
UniGeneiHs.643801.

Genome annotation databases

GeneIDi1462.

Similar proteinsi

Entry informationi

Entry nameiA0A024RAL1_HUMAN
AccessioniPrimary (citable) accession number: A0A024RAL1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation