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Protein
Submitted name:

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_c

Gene

MPP6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), isoform CRA_cImported
Gene namesi
Name:MPP6Imported
ORF Names:hCG_38837Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105926.15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiA0A024RA25.

Expressioni

Gene expression databases

BgeeiENSG00000105926.
ExpressionAtlasiA0A024RA25. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024RA25.
SMRiA0A024RA25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48L27InterPro annotationAdd BLAST48
Domaini49 – 107L27InterPro annotationAdd BLAST59
Domaini130 – 209PDZInterPro annotationAdd BLAST80
Domaini215 – 284SH3InterPro annotationAdd BLAST70
Domaini338 – 525Guanylate kinase-likeInterPro annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili510 – 530Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the MAGUK family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
OMAiDTIIPQQ.
OrthoDBiEOG091G065I.
PhylomeDBiA0A024RA25.

Family and domain databases

CDDicd12038. SH3_MPP6. 1 hit.
Gene3Di1.10.287.650. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR036892. L27_dom_sf.
IPR035603. MPP6_SH3.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024RA25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE
60 70 80 90 100
AVSDNNLELV NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA
110 120 130 140 150
SKCYDSPPSS PEMNNSSINN QLLPVDAIRI LGIHKRAGEP LGVTFRVENN
160 170 180 190 200
DLVIARILHG GMIDRQGLLH VGDIIKEVNG HEVGNNPKEL QELLKNISGS
210 220 230 240 250
VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG LKFSKGEILQ
260 270 280 290 300
IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT
310 320 330 340 350
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG
360 370 380 390 400
RRSLKNRFIV LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK
410 420 430 440 450
AGKYLEHGEY EGNLYGTKID SILEVVQTGR TCILDVNPQA LKVLRTSEFM
460 470 480 490 500
PYVVFIAAPE LETLRAMHKA VVDAGITTKL LTDSDLKKTV DESARIQRAY
510 520 530 540
NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY
Length:540
Mass (Da):61,117
Last modified:July 9, 2014 - v1
Checksum:i86310E4F6AF632BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471073 Genomic DNA. Translation: EAW93811.1.
RefSeqiNP_001289966.1. NM_001303037.1.
NP_057531.2. NM_016447.3.
XP_006715801.1. XM_006715738.3.
XP_006715802.1. XM_006715739.3.
XP_006715803.1. XM_006715740.3.
XP_011513727.1. XM_011515425.2.
XP_016867804.1. XM_017012315.1.
XP_016867805.1. XM_017012316.1.
XP_016867806.1. XM_017012317.1.
UniGeneiHs.533355.
Hs.563501.
Hs.594275.

Genome annotation databases

GeneIDi51678.
KEGGihsa:51678.

Similar proteinsi

Entry informationi

Entry nameiA0A024RA25_HUMAN
AccessioniPrimary (citable) accession number: A0A024RA25
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: January 31, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.