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Protein
Submitted name:

Mitogen-activated protein kinase kinase 6, isoform CRA_a

Gene

MAP2K6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase 6, isoform CRA_aImported
Gene namesi
Name:MAP2K6Imported
ORF Names:hCG_28772Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000468348.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 258Protein kinaseInterPro annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A024R8K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGRGAYGV VEKMRHVPSG QIMAVKRIRA TVNSQEQKRL LMDLDISMRT
60 70 80 90 100
VDCPFTVTFY GALFREGDVW ICMELMDTSL DKFYKQVIDK GQTIPEDILG
110 120 130 140 150
KIAVSIVKAL EHLHSKLSVI HRDVKPSNVL INALGQVKMC DFGISGYLVD
160 170 180 190 200
SVAKTIDAGC KPYMAPERIN PELNQKGYSV KSDIWSLGIT MIELAILRFP
210 220 230 240 250
YDSWGTPFQQ LKQVVEEPSP QLPADKFSAE FVDFTSQCLK KNSKERPTYP
260 270
ELMQHPFFTL HESKGTDVAS FVKLILGD
Length:278
Mass (Da):31,339
Last modified:July 9, 2014 - v1
Checksum:i1EE7FC1B26B11AE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA. Translation: EAW89084.1.
CH471099 Genomic DNA. Translation: EAW89086.1.
RefSeqiNP_001317379.1. NM_001330450.1.
XP_005257573.1. XM_005257516.2.
XP_006722038.1. XM_006721975.3.
XP_011523329.1. XM_011525027.2.
UniGeneiHs.463978.
Hs.49329.

Genome annotation databases

GeneIDi5608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA. Translation: EAW89084.1.
CH471099 Genomic DNA. Translation: EAW89086.1.
RefSeqiNP_001317379.1. NM_001330450.1.
XP_005257573.1. XM_005257516.2.
XP_006722038.1. XM_006721975.3.
XP_011523329.1. XM_011525027.2.
UniGeneiHs.463978.
Hs.49329.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000468348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5608.

Organism-specific databases

CTDi5608.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.

Miscellaneous databases

GenomeRNAii5608.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R8K3_HUMAN
AccessioniPrimary (citable) accession number: A0A024R8K3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 30, 2016
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.