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Protein

Multifunctional fusion protein

Gene

CACNG4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Voltage-dependent calcium channel gamma subunitUniRule annotation
Voltage-dependent calcium channel gamma-4 subunitUniRule annotation
Gene namesi
Name:CACNG4Imported
ORF Names:hCG_29241Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000075461.5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 28HelicalUniRule annotationAdd BLAST22
Transmembranei103 – 125HelicalUniRule annotationAdd BLAST23
Transmembranei137 – 161HelicalUniRule annotationAdd BLAST25
Transmembranei181 – 207HelicalUniRule annotationAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA0A024R8J8.

Expressioni

Gene expression databases

BgeeiENSG00000075461.
ExpressionAtlasiA0A024R8J8. baseline and differential.

Interactioni

Subunit structurei

The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A024R8J8.
SMRiA0A024R8J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IJYN. Eukaryota.
ENOG4111W1R. LUCA.
KOiK04869.
OMAiICNGTNL.
OrthoDBiEOG091G0D2Z.
PhylomeDBiA0A024R8J8.

Family and domain databases

InterProiView protein in InterPro
IPR004031. PMP22/EMP/MP20/Claudin.
IPR005423. VDCC_g4su.
IPR008368. VDCC_gsu.
PANTHERiPTHR12107:SF7. PTHR12107:SF7. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01792. VDCCGAMMA.
PR01603. VDCCGAMMA4.

Sequencei

Sequence statusi: Complete.

A0A024R8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD
60 70 80 90 100
GPPPRRARGD LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL
110 120 130 140 150
LRIVRASSVF PILSTILLLL GGLCIGAGRI YSRKNNIVLS AGILFVAAGL
160 170 180 190 200
SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN YGWSFYFGAL SFIVAETVGV
210 220 230 240 250
LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR RRSRSSSRST
260 270 280 290 300
EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF
310 320
LQVHDFFQQD LKEGFHVSML NRRTTPV
Length:327
Mass (Da):36,579
Last modified:July 9, 2014 - v1
Checksum:i79630ACC03B1DAE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471099 Genomic DNA. Translation: EAW89021.1.
RefSeqiNP_055220.1. NM_014405.3.
UniGeneiHs.514423.

Genome annotation databases

GeneIDi27092.
KEGGihsa:27092.

Similar proteinsi

Entry informationi

Entry nameiA0A024R8J8_HUMAN
AccessioniPrimary (citable) accession number: A0A024R8J8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.