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Protein
Submitted name:

Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_a

Gene

PTN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_aImported
Gene namesi
Name:PTNImported
ORF Names:hCG_18946Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 168136Sequence analysisPRO_5001533626Add
BLAST

Proteomic databases

PaxDbiA0A024R778.

Expressioni

Gene expression databases

ExpressionAtlasiA0A024R778. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341170.

Structurei

3D structure databases

ProteinModelPortaliA0A024R778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9562PTN_MK_NInterPro annotationAdd
BLAST
Domaini96 – 15863PTN_MK_CInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
KOiK16642.
OMAiRMQSQQY.
OrthoDBiEOG091G0VCN.
PhylomeDBiA0A024R778.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A024R778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,942
Last modified:July 9, 2014 - v1
Checksum:i0359C08B6497B579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471070 Genomic DNA. Translation: EAW83872.1.
RefSeqiNP_001308315.1. NM_001321386.1.
NP_002816.1. NM_002825.5.
UniGeneiHs.371249.

Genome annotation databases

GeneIDi5764.
KEGGihsa:5764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471070 Genomic DNA. Translation: EAW83872.1.
RefSeqiNP_001308315.1. NM_001321386.1.
NP_002816.1. NM_002825.5.
UniGeneiHs.371249.

3D structure databases

ProteinModelPortaliA0A024R778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341170.

Proteomic databases

PaxDbiA0A024R778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5764.
KEGGihsa:5764.

Organism-specific databases

CTDi5764.

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
KOiK16642.
OMAiRMQSQQY.
OrthoDBiEOG091G0VCN.
PhylomeDBiA0A024R778.

Miscellaneous databases

GenomeRNAii5764.

Gene expression databases

ExpressionAtlasiA0A024R778. baseline and differential.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R778_HUMAN
AccessioniPrimary (citable) accession number: A0A024R778
Entry historyi
Integrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 7, 2016
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.