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Protein
Submitted name:

Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_a

Gene

PTN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_aImported
Gene namesi
Name:PTNImported
ORF Names:hCG_18946Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000105894.11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_500153362633 – 168Sequence analysisAdd BLAST136

Proteomic databases

PaxDbiA0A024R778.
PRIDEiA0A024R778.

Expressioni

Gene expression databases

BgeeiENSG00000105894.
ExpressionAtlasiA0A024R778. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024R778.
SMRiA0A024R778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 95PTN_MK_NInterPro annotationAdd BLAST62
Domaini96 – 158PTN_MK_CInterPro annotationAdd BLAST63

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
KOiK16642.
OMAiGEDICNS.
OrthoDBiEOG091G0VCN.
PhylomeDBiA0A024R778.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
InterProiView protein in InterPro
IPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiView protein in Pfam
PF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
PRINTSiPR00269. PTNMIDKINE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592. PTN_MK_hepar_bd. 1 hit.
SMARTiView protein in SMART
SM00193. PTN. 1 hit.
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiView protein in PROSITE
PS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024R778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,942
Last modified:July 9, 2014 - v1
Checksum:i0359C08B6497B579
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471070 Genomic DNA. Translation: EAW83872.1.
RefSeqiNP_001308315.1. NM_001321386.2.
NP_002816.1. NM_002825.6.
UniGeneiHs.371249.

Genome annotation databases

GeneIDi5764.
KEGGihsa:5764.

Similar proteinsi

Entry informationi

Entry nameiA0A024R778_HUMAN
AccessioniPrimary (citable) accession number: A0A024R778
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 27, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.