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Protein

Non-specific serine/threonine protein kinase

Gene

MARK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:MARK2Imported
ORF Names:hCG_21366Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000072518.20.

Expressioni

Gene expression databases

BgeeiENSG00000072518.

Structurei

3D structure databases

SMRiA0A024R5B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 271Protein kinaseInterPro annotationAdd BLAST252
Domaini290 – 329UBAInterPro annotationAdd BLAST40
Domaini642 – 691KA1InterPro annotationAdd BLAST50

Family and domain databases

InterProiView protein in InterPro
IPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom_sf.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
PANTHERiPTHR24346. PTHR24346. 2 hits.
PfamiView protein in Pfam
PF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
PF00627. UBA. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024R5B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI
60 70 80 90 100
IDKTQLNSSS LQKLFREVRI MKVLNHPNIV KLFEVIETEK TLYLVMEYAS
110 120 130 140 150
GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKFIVH RDLKAENLLL
160 170 180 190 200
DADMNIKIAD FGFSNEFTFG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV
210 220 230 240 250
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK
260 270 280 290 300
FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV
310 320 330 340 350
SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL
360 370 380 390 400
TNSSAPSPSH KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSNNAEN
410 420 430 440 450
KRPEEDRESG RKASSTAKVP ASPLPGLERK KTTPTPSTNS VLSTSTNRSR
460 470 480 490 500
NSPLLERASL GQASIQNGKD STAPQRVPVA SPSAHNISSS GGAPDRTNFP
510 520 530 540 550
RGVSSRSTFH AGQLRQVRDQ QNLPYGVTPA SPSGHSQGRR GASGSIFSKF
560 570 580 590 600
TSKFVRRNLN EPESKDRVET LRPHVVGSGG NDKEKEEFRE AKPRSLRFTW
610 620 630 640 650
SMKTTSSMEP NEMMREIRKV LDANSCQSEL HEKYMLLCMH GTPGHEDFVQ
660 670 680 690
WEMEVCKLPR LSLNGVRFKR ISGTSMAFKN IASKIANELK L
Length:691
Mass (Da):77,631
Last modified:July 9, 2014 - v1
Checksum:i2216B4AE7BCF31BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471076 Genomic DNA. Translation: EAW74177.1.
CH471076 Genomic DNA. Translation: EAW74178.1.
UniGeneiHs.567261.

Similar proteinsi

Entry informationi

Entry nameiA0A024R5B2_HUMAN
AccessioniPrimary (citable) accession number: A0A024R5B2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.