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Protein
Submitted name:

HCG16983, isoform CRA_b

Gene

hCG_16983

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
HCG16983, isoform CRA_bImported
Gene namesi
ORF Names:hCG_16983Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000064012.21.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000064012.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80DEDInterPro annotationAdd BLAST79
Domaini100 – 177DEDInterPro annotationAdd BLAST78
Domaini217 – 349CASPASE_P20InterPro annotationAdd BLAST133
Domaini374 – 463CASPASE_P10InterPro annotationAdd BLAST90

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR033170. Caspase-8.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR001875. DED_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PANTHERiPTHR10454:SF162. PTHR10454:SF162. 1 hit.
PfamiView protein in Pfam
PF01335. DED. 2 hits.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00115. CASc. 1 hit.
SM00031. DED. 2 hits.
SUPFAMiSSF47986. SSF47986. 2 hits.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
PS50168. DED. 2 hits.

Sequencei

Sequence statusi: Complete.

A0A024R3Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE
60 70 80 90 100
KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA
110 120 130 140 150
YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV
160 170 180 190 200
ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKGEELCGV MTISDSPREQ
210 220 230 240 250
DSESQTLDKV YQMKSKPRGY CLIINNHNFA KAREKVPKLH SIRDRNGTHL
260 270 280 290 300
DAGALTTTFE ELHFEIKPHD DCTVEQIYEI LKIYQLMDHS NMDCFICCIL
310 320 330 340 350
SHGDKGIIYG TDGQEAPIYE LTSQFTGLKC PSLAGKPKVF FIQACQGDNY
360 370 380 390 400
QKGIPVETDS EEQPYLEMDL SSPQTRYIPD EADFLLGMAT VNNCVSYRNP
410 420 430 440 450
AEGTWYIQSL CQSLRERCPR GDDILTILTE VNYEVSNKDD KKNMGKQMPQ
460
PTFTLRKKLV FPSD
Length:464
Mass (Da):53,768
Last modified:July 9, 2014 - v1
Checksum:i7F52F14ADE6A02B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA. Translation: EAW70253.1.
CH471063 Genomic DNA. Translation: EAW70258.1.
RefSeqiNP_001073593.1. NM_001080124.1.
NP_203520.1. NM_033356.3.
XP_005246949.1. XM_005246892.1.
UniGeneiHs.599762.

Genome annotation databases

GeneIDi841.

Similar proteinsi

Entry informationi

Entry nameiA0A024R3Z8_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3Z8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 25, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.