Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Potassium channel, subfamily K, member 1, isoform CRA_a

Gene

KCNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel, subfamily K, member 1, isoform CRA_aImported
Gene namesi
Name:KCNK1Imported
ORF Names:hCG_15518Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4424HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15723HelicalSequence analysisAdd
BLAST
Transmembranei178 – 20326HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23218HelicalSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA0A024R3T2.

Expressioni

Gene expression databases

ExpressionAtlasiA0A024R3T2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355580.

Structurei

3D structure databases

ProteinModelPortaliA0A024R3T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 15768Ion_trans_2InterPro annotationAdd
BLAST
Domaini193 – 26775Ion_trans_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
KOiK04912.
OMAiKQLRKMF.
OrthoDBiEOG091G0DIX.
PhylomeDBiA0A024R3T2.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

A0A024R3T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED
60 70 80 90 100
LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW
110 120 130 140 150
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT
160 170 180 190 200
AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA
210 220 230 240 250
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT
260 270 280 290 300
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS
310 320 330
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH
Length:336
Mass (Da):38,143
Last modified:July 9, 2014 - v1
Checksum:i2A41D9501323215D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471098 Genomic DNA. Translation: EAW69990.1.
RefSeqiNP_002236.1. NM_002245.3.
UniGeneiHs.208544.

Genome annotation databases

GeneIDi3775.
KEGGihsa:3775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471098 Genomic DNA. Translation: EAW69990.1.
RefSeqiNP_002236.1. NM_002245.3.
UniGeneiHs.208544.

3D structure databases

ProteinModelPortaliA0A024R3T2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355580.

Proteomic databases

PaxDbiA0A024R3T2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3775.
KEGGihsa:3775.

Organism-specific databases

CTDi3775.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
KOiK04912.
OMAiKQLRKMF.
OrthoDBiEOG091G0DIX.
PhylomeDBiA0A024R3T2.

Miscellaneous databases

GenomeRNAii3775.

Gene expression databases

ExpressionAtlasiA0A024R3T2. baseline and differential.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R3T2_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3T2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 7, 2016
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.