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Protein

Potassium channel subfamily K member

Gene

KCNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelUniRule annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K memberUniRule annotation
Gene namesi
Name:KCNK1Imported
ORF Names:hCG_15518Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000135750.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalSequence analysisAdd BLAST24
Transmembranei135 – 157HelicalSequence analysisAdd BLAST23
Transmembranei178 – 203HelicalSequence analysisAdd BLAST26
Transmembranei215 – 232HelicalSequence analysisAdd BLAST18
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...) asparagineUniRule annotation1

Expressioni

Gene expression databases

BgeeiENSG00000135750
ExpressionAtlasiA0A024R3T2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA0A024R3T2
SMRiA0A024R3T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 157Ion_trans_2InterPro annotationAdd BLAST68
Domaini193 – 267Ion_trans_2InterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili53 – 73Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
KOiK04912
OMAiVQRVTIH
OrthoDBiEOG091G0DIX
PhylomeDBiA0A024R3T2

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR005408 2pore_dom_K_chnl_TWIK
IPR001779 2pore_dom_K_chnl_TWIK1
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01096 TWIK1CHANNEL
PR01586 TWIKCHANNEL

Sequencei

Sequence statusi: Complete.

A0A024R3T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED
60 70 80 90 100
LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW
110 120 130 140 150
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT
160 170 180 190 200
AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA
210 220 230 240 250
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT
260 270 280 290 300
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS
310 320 330
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH
Length:336
Mass (Da):38,143
Last modified:July 9, 2014 - v1
Checksum:i2A41D9501323215D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471098 Genomic DNA Translation: EAW69990.1
RefSeqiNP_002236.1, NM_002245.3
UniGeneiHs.208544

Genome annotation databases

GeneIDi3775
KEGGihsa:3775

Similar proteinsi

Entry informationi

Entry nameiA0A024R3T2_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3T2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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