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Protein
Submitted name:

Potassium channel, subfamily K, member 1, isoform CRA_a

Gene

KCNK1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel, subfamily K, member 1, isoform CRA_aImported
Gene namesi
Name:KCNK1Imported
ORF Names:hCG_15518Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000135750.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 44HelicalSequence analysisAdd BLAST24
Transmembranei135 – 157HelicalSequence analysisAdd BLAST23
Transmembranei178 – 203HelicalSequence analysisAdd BLAST26
Transmembranei215 – 232HelicalSequence analysisAdd BLAST18
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiA0A024R3T2.
PRIDEiA0A024R3T2.

Expressioni

Gene expression databases

BgeeiENSG00000135750.
ExpressionAtlasiA0A024R3T2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A024R3T2.
SMRiA0A024R3T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 157Ion_trans_2InterPro annotationAdd BLAST68
Domaini193 – 267Ion_trans_2InterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
KOiK04912.
OMAiVQRVTIH.
OrthoDBiEOG091G0DIX.
PhylomeDBiA0A024R3T2.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
IPR001779. 2pore_dom_K_chnl_TWIK1.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01096. TWIK1CHANNEL.
PR01586. TWIKCHANNEL.

Sequencei

Sequence statusi: Complete.

A0A024R3T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED
60 70 80 90 100
LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW
110 120 130 140 150
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT
160 170 180 190 200
AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA
210 220 230 240 250
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT
260 270 280 290 300
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS
310 320 330
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH
Length:336
Mass (Da):38,143
Last modified:July 9, 2014 - v1
Checksum:i2A41D9501323215D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471098 Genomic DNA. Translation: EAW69990.1.
RefSeqiNP_002236.1. NM_002245.3.
UniGeneiHs.208544.

Genome annotation databases

GeneIDi3775.
KEGGihsa:3775.

Similar proteinsi

Entry informationi

Entry nameiA0A024R3T2_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3T2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 27, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.