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Protein
Submitted name:

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_a

Gene

TIRAP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_aImported
Gene namesi
Name:TIRAPImported
ORF Names:hCG_2032769Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA0A024R3M4.

Expressioni

Gene expression databases

ExpressionAtlasiA0A024R3M4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376445.

Structurei

3D structure databases

ProteinModelPortaliA0A024R3M4.
SMRiA0A024R3M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 168TIRInterPro annotationAdd BLAST85

Phylogenomic databases

eggNOGiENOG410IVIY. Eukaryota.
ENOG411205V. LUCA.
KOiK05403.
PhylomeDBiA0A024R3M4.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000157. TIR_dom.
IPR017279. Tol-interleuk_rcpt_adapt_Tirap.
[Graphical view]
PANTHERiPTHR22662. PTHR22662. 1 hit.
PfamiPF13676. TIR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037750. TIR_Tirap. 1 hit.
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A0A024R3M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTSLPAP GSRPKKPLGK MADWFRQTLL KKPKKRPNSP ESTSSDASQP
60 70 80 90 100
TSQDSPLPPS LSSVTSPSLP PTHASDSGSS RWSKDYDVCV CHSEEDLVAA
110 120 130 140 150
QDLVSYLEGS TASLRCFLQL RDATPGGAIV SELCQALSSS HCRVLLITPG
160 170 180 190 200
FLQDPWCKYQ MLQALTEAPG AEGCTIPLLS GLSRAAYPPE LRFMYYVDGR
210 220
GPDGGFRQVK EAVMRYLQTL S
Length:221
Mass (Da):23,883
Last modified:July 9, 2014 - v1
Checksum:i44A8454D04704540
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA. Translation: EAW67688.1.
RefSeqiNP_001034750.1. NM_001039661.1.
NP_001305706.1. NM_001318777.1.
XP_011540878.1. XM_011542576.2.
XP_016872651.1. XM_017017162.1.
UniGeneiHs.537126.

Genome annotation databases

GeneIDi114609.
KEGGihsa:114609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471065 Genomic DNA. Translation: EAW67688.1.
RefSeqiNP_001034750.1. NM_001039661.1.
NP_001305706.1. NM_001318777.1.
XP_011540878.1. XM_011542576.2.
XP_016872651.1. XM_017017162.1.
UniGeneiHs.537126.

3D structure databases

ProteinModelPortaliA0A024R3M4.
SMRiA0A024R3M4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376445.

Proteomic databases

PaxDbiA0A024R3M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114609.
KEGGihsa:114609.

Organism-specific databases

CTDi114609.

Phylogenomic databases

eggNOGiENOG410IVIY. Eukaryota.
ENOG411205V. LUCA.
KOiK05403.
PhylomeDBiA0A024R3M4.

Miscellaneous databases

GenomeRNAii114609.

Gene expression databases

ExpressionAtlasiA0A024R3M4. baseline and differential.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000157. TIR_dom.
IPR017279. Tol-interleuk_rcpt_adapt_Tirap.
[Graphical view]
PANTHERiPTHR22662. PTHR22662. 1 hit.
PfamiPF13676. TIR_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037750. TIR_Tirap. 1 hit.
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024R3M4_HUMAN
AccessioniPrimary (citable) accession number: A0A024R3M4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 2, 2016
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.