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Protein

Poly [ADP-ribose] polymerase

Gene

PARP3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:PARP3Imported
ORF Names:hCG_42577Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000041880.14

Expressioni

Gene expression databases

BgeeiENSG00000041880
ExpressionAtlasiA0A024R2X5 baseline and differential

Structurei

3D structure databases

SMRiA0A024R2X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 300PARP alpha-helicalInterPro annotationAdd BLAST119
Domaini313 – 533PARP catalyticInterPro annotationAdd BLAST221

Phylogenomic databases

eggNOGiKOG1037 Eukaryota
ENOG410XP18 LUCA
KOiK10798

Family and domain databases

Gene3Di1.20.142.10, 1 hit
2.20.140.10, 1 hit
InterProiView protein in InterPro
IPR031275 PARP3
IPR012317 Poly(ADP-ribose)pol_cat_dom
IPR004102 Poly(ADP-ribose)pol_reg_dom
IPR036616 Poly(ADP-ribose)pol_reg_dom_sf
IPR036930 WGR_dom_sf
IPR008893 WGR_domain
PANTHERiPTHR10459:SF66 PTHR10459:SF66, 1 hit
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PF02877 PARP_reg, 1 hit
PF05406 WGR, 1 hit
SMARTiView protein in SMART
SM00773 WGR, 1 hit
SUPFAMiSSF142921 SSF142921, 1 hit
SSF47587 SSF47587, 1 hit
PROSITEiView protein in PROSITE
PS51060 PARP_ALPHA_HD, 1 hit
PS51059 PARP_CATALYTIC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024R2X5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKPKPWVQ TEGPEKKKGR QAGREEDPFR STAEALKAIP AEKRIIRVDP
60 70 80 90 100
TCPLSSNPGT QVYEDYNCTL NQTNIENNNN KFYIIQLLQD SNRFFTCWNR
110 120 130 140 150
WGRVGEVGQS KINHFTRLED AKKDFEKKFR EKTKNNWAER DHFVSHPGKY
160 170 180 190 200
TLIEVQAEDE AQEAVVKVDR GPVRTVTKRV QPCSLDPATQ KLITNIFSKE
210 220 230 240 250
MFKNTMALMD LDVKKMPLGK LSKQQIARGF EALEALEEAL KGPTDGGQSL
260 270 280 290 300
EELSSHFYTV IPHNFGHSQP PPINSPELLQ AKKDMLLVLA DIELAQALQA
310 320 330 340 350
VSEQEKTVEE VPHPLDRDYQ LLKCQLQLLD SGAPEYKVIQ TYLEQTGSNH
360 370 380 390 400
RCPTLQHIWK VNQEGEEDRF QAHSKLGNRK LLWHGTNMAV VAAILTSGLR
410 420 430 440 450
IMPHSGGRVG KGIYFASENS KSAGYVIGMK CGAHHVGYMF LGEVALGREH
460 470 480 490 500
HINTDNPSLK SPPPGFDSVI ARGHTEPDPT QDTELELDGQ QVVVPQGQPV
510 520 530
PCPEFSSSTF SQSEYLIYQE SQCRLRYLLE VHL
Length:533
Mass (Da):60,089
Last modified:July 9, 2014 - v1
Checksum:i6296A0E439CC7767
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471055 Genomic DNA Translation: EAW65160.1
CH471055 Genomic DNA Translation: EAW65162.1
CH471055 Genomic DNA Translation: EAW65163.1
RefSeqiNP_005476.4, NM_005485.5
XP_005264836.2, XM_005264779.4
XP_016860979.1, XM_017005490.1
UniGeneiHs.271742

Genome annotation databases

GeneIDi10039
KEGGihsa:10039
UCSCiuc003dby.3 human

Similar proteinsi

Entry informationi

Entry nameiA0A024R2X5_HUMAN
AccessioniPrimary (citable) accession number: A0A024R2X5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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