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Protein
Submitted name:

MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), isoform CRA_a

Gene

MLH1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), isoform CRA_aImported
Gene namesi
Name:MLH1Imported
ORF Names:hCG_17142Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000076242.14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiA0A024R2S9.
PRIDEiA0A024R2S9.

Expressioni

Gene expression databases

BgeeiENSG00000076242.
ExpressionAtlasiA0A024R2S9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA0A024R2S9.
SMRiA0A024R2S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94DNA_mis_repairInterPro annotationAdd BLAST94

Phylogenomic databases

eggNOGiKOG1979. Eukaryota.
COG0323. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR013507. DNA_mismatch_repair_C.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 1 hit.
SMARTiView protein in SMART
SM01340. DNA_mis_repair. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024R2S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYISNANY SVKKCIFLLF INHRLVESTS LRKAIETVYA AYLPKNTHPF
60 70 80 90 100
LYLSLEISPQ NVDVNVHPTK HEVHFLHEES ILERVQQHIE SKLLGSNSSR
110 120 130 140 150
MYFTQTLLPG LAGPSGEMVK STTSLTSSST SGSSDKVYAH QMVRTDSREQ
160 170 180 190 200
KLDAFLQPLS KPLSSQPQAI VTEDKTDISS GRARQQDEEM LELPAPAEVA
210 220 230 240 250
AKNQSLEGDT TKGTSEMSEK RGPTSSNPRK RHREDSDVEM VEDDSRKEMT
260 270 280 290 300
AACTPRRRII NLTSVLSLQE EINEQGHEVL REMLHNHSFV GCVNPQWALA
310 320 330 340 350
QHQTKLYLLN TTKLSEELFY QILIYDFANF GVLRLSEPAP LFDLAMLALD
360 370 380 390 400
SPESGWTEED GPKEGLAEYI VEFLKKKAEM LADYFSLEID EEGNLIGLPL
410 420 430 440 450
LIDNYVPPLE GLPIFILRLA TEVNWDEEKE CFESLSKECA MFYSIRKQYI
460 470 480 490 500
SEESTLSGQQ SEVPGSIPNS WKWTVEHIVY KALRSHILPP KHFTEDGNIL
510
QLANLPDLYK VFERC
Length:515
Mass (Da):58,375
Last modified:July 9, 2014 - v1
Checksum:iDCD9320AB8E5ADF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471055 Genomic DNA. Translation: EAW64484.1.
RefSeqiNP_001161090.1. NM_001167618.1.
NP_001161091.1. NM_001167619.1.
NP_001245202.1. NM_001258273.1.
NP_001245203.1. NM_001258274.1.
XP_005265220.1. XM_005265163.1.
XP_005265221.1. XM_005265164.1.
UniGeneiHs.195364.

Genome annotation databases

GeneIDi4292.

Similar proteinsi

Entry informationi

Entry nameiA0A024R2S9_HUMAN
AccessioniPrimary (citable) accession number: A0A024R2S9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 27, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.