LMAN1

Functionⁱ

GO - Molecular functionⁱ

mannose binding Source: InterPro

GO - Biological processⁱ

endoplasmic reticulum organization Source: Ensembl
ER to Golgi vesicle-mediated transport Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Lectin, mannose-binding, 1, isoform CRA_bImported
Gene namesⁱ	Name:LMAN1Imported ORF Names:hCG_1979190Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	479 – 498	HelicalSequence analysisAdd BLAST		20

GO - Cellular componentⁱ

endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
ER to Golgi transport vesicle Source: Ensembl
Golgi apparatus Source: Ensembl
integral component of membrane Source: UniProtKB-KW
sarcomere Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 30	Sequence analysisAdd BLAST		30
ChainⁱPRO_5010010642	31 – 510	Sequence analysisAdd BLAST		480

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000074695.
ExpressionAtlasⁱ	A0A024R2A7. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	A0A024R2A7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 267	L-type lectin-likeInterPro annotationAdd BLAST		224

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	279 – 306	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3838. Eukaryota. ENOG410ZFRX. LUCA.
KEGG Orthology (KO) More...KOⁱ	K10080.
OMAⁱ	NMIIPAQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08WZ.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320. ConA-like_dom. IPR005052. Lectin_leg. IPR033085. LMAN1.
PANTHERⁱ	PTHR12223:SF34. PTHR12223:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03388. Lectin_leg-like. 1 hit.
SUPFAMⁱ	SSF49899. SSF49899. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51328. L_LECTIN_LIKE. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024R2A7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGSRQRGLR ARVRPLFCAL LLSLGRFVRG DGVGGDPAVA LPHRRFEYKY 
        60         70         80         90        100
SFKGPHLVQS DGTVPFWAHA GNAIPSSDQI RVAPSLKSQR GSVWTKTKAA 
       110        120        130        140        150
FENWEVEVTF RVTGRGRIGA DGLAIWYAEN QGLEGPVFGS ADLWNGVGIF 
       160        170        180        190        200
FDSFDNDGKK NNPAIVIIGN NGQIHYDHQN DGASQALASC QRDFRNKPYP 
       210        220        230        240        250
VRAKITYYQN TLTVMINNGF TPDKNDYEFC AKVENMIIPA QGHFGISAAT 
       260        270        280        290        300
GGLADDHDVL SFLTFQLTEP GKEPPTPDKE ISEKEKEKYQ EEFEHFQQEL 
       310        320        330        340        350
DKKKEEFQKG HPDLQGQPAE EIFESVGDRE LRQVFEGQNR IHLEIKQLNR 
       360        370        380        390        400
QLDMILDEQR RYVSSLTEEI SKRGAGMPGQ HGQITQQELD TVVKTQHEIL 
       410        420        430        440        450
RQVNEMKNSM SETVRLVSGM QHPGSAGGVY ETTQHFIDIK EHLHIVKRDI 
       460        470        480        490        500
DNLVQRNMPS NEKPKCPELP PFPSCLSTVH FIIFVVVQTV LFIGYIMYRS 
       510
QQEAAAKKFF

Length:510

Mass (Da):57,549

Last modified:July 9, 2014 - v1

Checksum:ⁱB87EF117C0CD386C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471096 Genomic DNA. Translation: EAW63097.1. CH471096 Genomic DNA. Translation: EAW63098.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005561.1. NM_005570.3.
UniGeneⁱ	Hs.465295.

Genome annotation databases

GeneIDⁱ	3998.
KEGGⁱ	hsa:3998.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A0A024R2A7	P49257 UPI0001C0BFE8	Homo sapiens (Human)	510	UniRef100_P49257	Cluster: Protein ERGIC-53	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A0A024R2A7	Q9TU32 A0A0D9RZZ9 G3TQ49 UPI00042C5B6F UPI000938B790 UPI0003C8DE4D K9IL36 UPI000333F6B6 A0A0P6JIH3 UPI0002C31DBC +76	Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Loxodonta africana (African elephant) Physeter catodon (Sperm whale) (Physeter macrocephalus) Hipposideros armiger (great roundleaf bat) Tupaia chinensis (Chinese tree shrew) Desmodus rotundus (Vampire bat) Echinops telfairi (Lesser hedgehog tenrec) Heterocephalus glaber (Naked mole rat) Tursiops truncatus (Atlantic bottle-nosed dolphin) (Delphinus truncatus) And more	510	UniRef90_Q9TU32	Cluster: Protein ERGIC-53	87

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
A0A024R2A7	Q62902 UPI0000111A11 Q3U944 A0A0P6CF66 UPI000B4F00D9 UPI00042AC59E A0A0G2JXC1 UPI00038BDA15 UPI0004545E51 UPI000A3192D8 +306	Rattus norvegicus (Rat) Mus musculus (Mouse) Daphnia magna Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Peromyscus maniculatus bairdii (prairie deer mouse) Microtus ochrogaster (Prairie vole) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Mesocricetus auratus (Golden hamster) And more	517	UniRef50_Q62902	Cluster: Protein ERGIC-53	317

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471096 Genomic DNA. Translation: EAW63097.1. CH471096 Genomic DNA. Translation: EAW63098.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_005561.1. NM_005570.3.
UniGeneⁱ	Hs.465295.

3D structure databases

SMRⁱ	A0A024R2A7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	3998.
KEGGⁱ	hsa:3998.

Organism-specific databases

CTDⁱ	3998.

CTDⁱ

3998.

Phylogenomic databases

eggNOGⁱ	KOG3838. Eukaryota. ENOG410ZFRX. LUCA.
KEGG Orthology (KO) More...KOⁱ	K10080.
OMAⁱ	NMIIPAQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08WZ.

Miscellaneous databases

GenomeRNAiⁱ	3998.

GenomeRNAiⁱ

3998.

Gene expression databases

Bgeeⁱ	ENSG00000074695.
ExpressionAtlasⁱ	A0A024R2A7. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR013320. ConA-like_dom. IPR005052. Lectin_leg. IPR033085. LMAN1.
PANTHERⁱ	PTHR12223:SF34. PTHR12223:SF34. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03388. Lectin_leg-like. 1 hit.
SUPFAMⁱ	SSF49899. SSF49899. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51328. L_LECTIN_LIKE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024R2A7_HUMAN
Accessionⁱ	A0A024R2A7Primary (citable) accession number: A0A024R2A7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	August 30, 2017
	This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - A0A024R2A7 (A0A024R2A7_HUMAN)

Your basket is currently empty.

Lectin, mannose-binding, 1, isoform CRA_b

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Topology

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A024R2A7 (A0A024R2A7_HUMAN)

Your basket is currently empty.

Lectin, mannose-binding, 1, isoform CRA_b

LMAN1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ