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Protein
Submitted name:

Breast cancer 1, early onset, isoform CRA_d

Gene

BRCA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer 1, early onset, isoform CRA_dImported
Gene namesi
Name:BRCA1Imported
ORF Names:hCG_16943Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSG00000012048.
ExpressionAtlasiA0A024R1V0. baseline and differential.

Structurei

3D structure databases

SMRiA0A024R1V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 65RING-typeInterPro annotationAdd BLAST42
Domaini538 – 632BRCTInterPro annotationAdd BLAST95
Domaini652 – 751BRCTInterPro annotationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili294 – 321Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITQ4. Eukaryota.
ENOG4112BIH. LUCA.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di3.30.40.10. 1 hit.
3.40.50.10190. 2 hits.
InterProiView protein in InterPro
IPR011364. BRCA1.
IPR031099. BRCA1-associated.
IPR001357. BRCT_dom.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
PANTHERiPTHR13763. PTHR13763. 1 hit.
PTHR13763:SF3. PTHR13763:SF3. 1 hit.
PfamiView protein in Pfam
PF00533. BRCT. 2 hits.
PF00097. zf-C3HC4. 1 hit.
PIRSFiPIRSF001734. BRCA1. 2 hits.
SMARTiView protein in SMART
SM00292. BRCT. 2 hits.
SM00184. RING. 1 hit.
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiView protein in PROSITE
PS50172. BRCT. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024R1V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLSALRVEE VQNVINAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK
60 70 80 90 100
LLNQKKGPSQ CPLCKNDITK RSLQESTRFS QLVEELLKII CAFQLDTGLE
110 120 130 140 150
YANSYNFAKK ENNSPEHLKD EVSIIQSMGY RNRAKRLLQS EPENPSLQET
160 170 180 190 200
SLSVQLSNLG TVRTLRTKQR IQPQKTSVYI ELGSDSSEDT VNKATYCSVG
210 220 230 240 250
DQELLQITPQ GTRDEISLDS AKKAACEFSE TDVTNTEHHQ PSNNDLNTTE
260 270 280 290 300
KRAAERHPEK YQGEAASGCE SETSVSEDCS GLSSQSDILT TQQRDTMQHN
310 320 330 340 350
LIKLQQEMAE LEAVLEQHGS QPSNSYPSII SDSSALEDLR NPEQSTSEKV
360 370 380 390 400
LTSQKSSEYP ISQNPEGLSA DKFEVSADSS TSKNKEPGVE RSSPSKCPSL
410 420 430 440 450
DDRWYMHSCS GSLQNRNYPS QEELIKVVDV EEQQLEESGP HDLTETSYLP
460 470 480 490 500
RQDLEGTPYL ESGISLFSDD PESDPSEDRA PESARVGNIP SSTSALKVPQ
510 520 530 540 550
LKVAESAQSP AAAHTTDTAG YNAMEESVSR EKPELTASTE RVNKRMSMVV
560 570 580 590 600
SGLTPEEFML VYKFARKHHI TLTNLITEET THVVMKTDAE FVCERTLKYF
610 620 630 640 650
LGIAGGKWVV SYFWVTQSIK ERKMLNEHDF EVRGDVVNGR NHQGPKRARE
660 670 680 690 700
SQDRKIFRGL EICCYGPFTN MPTDQLEWMV QLCGASVVKE LSSFTLGTGV
710 720 730 740 750
HPIVVVQPDA WTEDNGFHAI GQMCEAPVVT REWVLDSVAL YQCQELDTYL

IPQIPHSHY
Length:759
Mass (Da):85,001
Last modified:July 9, 2014 - v1
Checksum:i29C7B9FF1660BD5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471152 Genomic DNA. Translation: EAW60925.1.
CH471152 Genomic DNA. Translation: EAW60932.1.
RefSeqiNP_009229.2. NM_007298.3.
UniGeneiHs.194143.

Genome annotation databases

GeneIDi672.

Similar proteinsi

Entry informationi

Entry nameiA0A024R1V0_HUMAN
AccessioniPrimary (citable) accession number: A0A024R1V0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 30, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.