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Protein
Submitted name:

Neurotrophin 5 (Neurotrophin 4/5), isoform CRA_a

Gene

NTF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurotrophin 5 (Neurotrophin 4/5), isoform CRA_aImported
Gene namesi
Name:NTF5Imported
ORF Names:hCG_1749438Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000225950.7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501421417025 – 210Sequence analysisAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 170UniRule annotation
Disulfide bondi141 ↔ 199UniRule annotation
Disulfide bondi158 ↔ 201UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000225950
ExpressionAtlasiA0A024QZE4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA0A024QZE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 202NGFInterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the NGF-beta family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIFY Eukaryota
ENOG4111839 LUCA
KOiK12457
OMAiSVPMEPH
OrthoDBiEOG091G0GHL

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 2 hits
PRINTSiPR01915 NEUROTROPHN4
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024QZE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR
60 70 80 90 100
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV
110 120 130 140 150
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG
160 170 180 190 200
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV
210
CTLLSRTGRA
Length:210
Mass (Da):22,427
Last modified:July 9, 2014 - v1
Checksum:iDBC6A30195E139AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA Translation: EAW52441.1
CH471177 Genomic DNA Translation: EAW52442.1
CH471177 Genomic DNA Translation: EAW52443.1
RefSeqiNP_006170.1, NM_006179.4
XP_005259019.1, XM_005258962.3
XP_006723295.1, XM_006723232.3
XP_011525311.1, XM_011527009.2
XP_011525312.1, XM_011527010.2
UniGeneiHs.266902
Hs.743915

Genome annotation databases

GeneIDi4909
KEGGihsa:4909

Similar proteinsi

Entry informationi

Entry nameiA0A024QZE4_HUMAN
AccessioniPrimary (citable) accession number: A0A024QZE4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: May 23, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health