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Protein
Submitted name:

Neurotrophin 5 (Neurotrophin 4/5), isoform CRA_a

Gene

NTF5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neurotrophin 5 (Neurotrophin 4/5), isoform CRA_aImported
Gene namesi
Name:NTF5Imported
ORF Names:hCG_1749438Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501001060025 – 210Sequence analysisAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 170UniRule annotation
Disulfide bondi141 ↔ 199UniRule annotation
Disulfide bondi158 ↔ 201UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301411.

Structurei

3D structure databases

SMRiA0A024QZE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 202NGFInterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the NGF-beta family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG091G0GHL.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiView protein in Pfam
PF00243. NGF. 1 hit.
PIRSFiPIRSF001789. NGF. 2 hits.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052. Nerve_growth_factor-rel. 1 hit.
SMARTiView protein in SMART
SM00140. NGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00248. NGF_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024QZE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR
60 70 80 90 100
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV
110 120 130 140 150
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG
160 170 180 190 200
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV
210
CTLLSRTGRA
Length:210
Mass (Da):22,427
Last modified:July 9, 2014 - v1
Checksum:iDBC6A30195E139AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA. Translation: EAW52441.1.
CH471177 Genomic DNA. Translation: EAW52442.1.
CH471177 Genomic DNA. Translation: EAW52443.1.
RefSeqiNP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.3.
XP_006723295.1. XM_006723232.3.
XP_011525311.1. XM_011527009.2.
XP_011525312.1. XM_011527010.2.
UniGeneiHs.266902.
Hs.743915.

Genome annotation databases

GeneIDi4909.
KEGGihsa:4909.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA. Translation: EAW52441.1.
CH471177 Genomic DNA. Translation: EAW52442.1.
CH471177 Genomic DNA. Translation: EAW52443.1.
RefSeqiNP_006170.1. NM_006179.4.
XP_005259019.1. XM_005258962.3.
XP_006723295.1. XM_006723232.3.
XP_011525311.1. XM_011527009.2.
XP_011525312.1. XM_011527010.2.
UniGeneiHs.266902.
Hs.743915.

3D structure databases

SMRiA0A024QZE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4909.
KEGGihsa:4909.

Organism-specific databases

CTDi4909.

Phylogenomic databases

eggNOGiENOG410IIFY. Eukaryota.
ENOG4111839. LUCA.
KOiK12457.
OMAiSVPMEPH.
OrthoDBiEOG091G0GHL.

Miscellaneous databases

GenomeRNAii4909.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR020432. Neurotrophin-4.
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiView protein in Pfam
PF00243. NGF. 1 hit.
PIRSFiPIRSF001789. NGF. 2 hits.
PRINTSiPR01915. NEUROTROPHN4.
PR00268. NGF.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052. Nerve_growth_factor-rel. 1 hit.
SMARTiView protein in SMART
SM00140. NGF. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00248. NGF_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024QZE4_HUMAN
AccessioniPrimary (citable) accession number: A0A024QZE4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 7, 2017
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.