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Protein

4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

BN975_03530

Organism
Mycobacterium farcinogenes
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.UniRule annotationSAAS annotation

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.UniRule annotationSAAS annotation
Oxaloacetate = pyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-4-methyl-2-oxoglutarate aldolaseUniRule annotationSAAS annotation (EC:4.1.1.3UniRule annotation, EC:4.1.3.17UniRule annotationSAAS annotation)
Short name:
HMG aldolaseUniRule annotation
Alternative name(s):
Oxaloacetate decarboxylaseUniRule annotation
Gene namesi
ORF Names:BN975_03530Imported
OrganismiMycobacterium farcinogenesImported
Taxonomic identifieri1802 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000030709 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd16841. RraA_family. 1 hit.
Gene3Di3.50.30.40. 1 hit.
InterProiView protein in InterPro
IPR010203. RraA.
IPR005493. RraA/RraA-like.
IPR036704. RraA/RraA-like_sf.
PfamiView protein in Pfam
PF03737. RraA-like. 1 hit.
SUPFAMiSSF89562. SSF89562. 1 hit.
TIGRFAMsiTIGR01935. NOT-MenG. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024M3B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDERAKCRP PAACDNRRVS IEPRATADLV DEIYPDVRSC DLQLQNYGGK
60 70 80 90 100
AMFAGPITTV RCFQDNALLK SILSTPGNGG VLVVDGDGSL HTALVGDIIA
110 120 130 140 150
GLAADNGWSG VIVHGAVRDA AALRTIDVGI KALGTNPRKG TKTGEGERDV
160 170
EVSFGGVTFV PGEIAYADED GIVLVAP
Length:177
Mass (Da):18,449
Last modified:July 9, 2014 - v1
Checksum:i28CE22B4922FEE30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG964482 Genomic DNA. Translation: CDP87710.1.

Genome annotation databases

EnsemblBacteriaiCDP87710; CDP87710; BN975_03530.

Similar proteinsi

Entry informationi

Entry nameiA0A024M3B1_9MYCO
AccessioniPrimary (citable) accession number: A0A024M3B1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 22, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported