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Protein

Putrescine aminotransferase

Gene

patA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (ygjG), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA), Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00188; UER00290.

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotationImported
ORF Names:EC3234A_52c00130Imported, EL75_0612Imported, EL79_0634Imported, EL80_0627Imported, HMPREF3040_02069Imported, PGD_04038Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000070450 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei337N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Putrescine aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8Y. Bacteria.
COG4992. LUCA.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01276. Putres_aminotrans_3. 1 hit.
InterProiView protein in InterPro
IPR005814. Aminotrans_3.
IPR017747. Putrescine_aminotransferase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PfamiView protein in Pfam
PF00202. Aminotran_3. 1 hit.
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 2 hits.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03372. putres_am_tran. 1 hit.
PROSITEiView protein in PROSITE
PS00600. AA_TRANSFER_CLASS_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A024L9J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITEFVFIPI FAIAAGVAQS LQYLNRYHVI REPPEHILNR LPSSASALAC
60 70 80 90 100
SAHALNLIEK RTLDHEEMKA LNREVIEYFK EHVNPGFLEY RKSVTAGGDY
110 120 130 140 150
GAVEWQAGSL NTLVDTQGQE FIDCLGGFGI FNVGHRNPVV VSAVQNQLAK
160 170 180 190 200
QPLHSQELLD PLRAMLAKTL AALTPGKLKY SFFCNSGTES VEAALKLAKA
210 220 230 240 250
YQSPRGKFTF IATSGAFHGK SLGALSATAK STFRKPFMPL LPGFRHVPFG
260 270 280 290 300
NIEAMRTALN ECKKTGDDVA AVILEPIQGE GGVILPPPGY LTAVRKLCDE
310 320 330 340 350
FGALMILDEV QTGMGRTGKM FACEHENVQP DILCLAKALG GGVMPIGATI
360 370 380 390 400
ATEEVFSVLF DNPFLHTTTF GGNPLACAAA LATINVLLEQ NLPAQAEQKG
410 420 430 440 450
DMLLDGFRQL AREYPDLVQE ARGKGMLMAI EFVDNEIGYN FASEMFRQRV
460 470 480 490
LVAGTLNNAK TIRIEPPLTL TIEQCELVIK AARKALAAMR VSVEEA
Length:496
Mass (Da):53,910
Last modified:July 9, 2014 - v1
Checksum:iF6FE1D90AC3F44F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HG976963 Genomic DNA. Translation: CDU41038.1.
JPKH01000003 Genomic DNA. Translation: KGM72003.1.
JPKL01000009 Genomic DNA. Translation: KGM83624.1.
JPMZ01000002 Genomic DNA. Translation: KGM85554.1.
LSNZ01000076 Genomic DNA. Translation: KXG99471.1.
LCVH01000052 Genomic DNA. Translation: OAC42867.1.

Genome annotation databases

EnsemblBacteriaiCDU41038; CDU41038; PGD_04038.
KGM72003; KGM72003; EL75_0612.
KGM83624; KGM83624; EL80_0627.
KGM85554; KGM85554; EL79_0634.
KXG99471; KXG99471; HMPREF3040_02069.
OAC42867; OAC42867; EC3234A_52c00130.
PATRICifig|562.10493.peg.4371.

Similar proteinsi

Entry informationi

Entry nameiA0A024L9J0_ECOLX
AccessioniPrimary (citable) accession number: A0A024L9J0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 27, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported