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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Acey_s0326.g2573

Organism
Ancylostoma ceylanicum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Acey_s0015.g2818), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Acey_s0287.g1454), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Acey_s0287.g1456), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Acey_s0015.g2818), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Acey_s0326.g2573), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (ANCCEY_01232)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, UbiquinoneImported

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Acey_s0326.g2573Imported
ORF Names:ANCCEY_05338Imported, Y032_0326g2573Imported
OrganismiAncylostoma ceylanicumImported
Taxonomic identifieri53326 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaStrongylidaAncylostomatoideaAncylostomatidaeAncylostomatinaeAncylostoma
Proteomesi
  • UP000024635 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 1282Fe-2S ferredoxin-typeInterPro annotationAdd BLAST92
Domaini171 – 2014Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.1060.10. 1 hit.
3.10.20.30. 1 hit.
InterProiView protein in InterPro
IPR036010. 2Fe-2S_ferredoxin-like_sf.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom_sf.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
PfamiView protein in Pfam
PF13085. Fer2_3. 1 hit.
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiView protein in PROSITE
PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A016S0T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLARSLLLAR GDAVVLASRS ASAAPPSKPT GSKIKTFEIY RFNPDKPGAK
60 70 80 90 100
PEMQKYDVDL NDCGSMVLDA LIKIKNEVDP TLTFRRSCRE GICGSCAMNI
110 120 130 140 150
GGQNTLACIQ KIDTDTSKPT KIFPLPHMFV VKDLVPDMNL FYEQYASIQP
160 170 180 190 200
WLQRKSEIKL GEQQLHQSVK ERAKLDGLYE CILCACCSTS CPSYWWNADK
210 220 230 240 250
YLGPAVLMQA YRWITDSRDD YAKERLSRMH DAYSAFKCHT IMNCTKTCPK
260 270
HLNPAKAIGE IKSLLTGLKT KPAPEPAKF
Length:279
Mass (Da):31,251
Last modified:June 11, 2014 - v1
Checksum:i610A1BC5ED566D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE124896 Genomic DNA. Translation: EPB75561.1.
JARK01001662 Genomic DNA. Translation: EYB83957.1.

Similar proteinsi

Entry informationi

Entry nameiA0A016S0T8_9BILA
AccessioniPrimary (citable) accession number: A0A016S0T8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: December 20, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported