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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Acinetobacter sp. 479375
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotationSAAS annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi67MagnesiumUniRule annotation1
Metal bindingi139MagnesiumUniRule annotation1
Metal bindingi142MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotationSAAS annotation (EC:3.1.22.4UniRule annotationSAAS annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotationImported
ORF Names:J500_0404Imported
OrganismiAcinetobacter sp. 479375Imported
Taxonomic identifieri1310601 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000020573 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotationSAAS annotation

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC. 1 hit.
InterProiView protein in InterPro
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
PANTHERiPTHR30194. PTHR30194. 1 hit.
PfamiView protein in Pfam
PF02075. RuvC. 1 hit.
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiView protein in PROSITE
PS01321. RUVC. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A009ZN07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLIIGIDPG SRLTGYGIIE KDGGQLRFID AGTIRTESQD MPERLKRIFA
60 70 80 90 100
GVERIVKFHG PTEAAVEQVF MAQNPDSALK LGQARGAAIA ALVNLDLQVA
110 120 130 140 150
EYTARQIKQS VVGYGAADKE QVQMMVMRIL SLTIKPQADA ADALAAAICH
160 170 180
AHVSGSMSKM AVLNALGGMA RGRSRYNSRR R
Length:181
Mass (Da):19,494
Last modified:June 11, 2014 - v1
Checksum:i4229AC648F0041C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JEZN01000001 Genomic DNA. Translation: EXD37943.1.
RefSeqiWP_034697892.1. NZ_JEZN01000001.1.

Genome annotation databases

EnsemblBacteriaiEXD37943; EXD37943; J500_0404.
PATRICifig|1310601.3.peg.389.

Similar proteinsi

Entry informationi

Entry nameiA0A009ZN07_9GAMM
AccessioniPrimary (citable) accession number: A0A009ZN07
Entry historyiIntegrated into UniProtKB/TrEMBL: June 11, 2014
Last sequence update: June 11, 2014
Last modified: October 25, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported