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Introduction

Number of entries
New entries 199
Updated entries 146,788
Unchanged entries 410,025
Total 557,012
Entries with updated sequences 184
With a fragmented AA sequence 9,152
With known alternative products 25,139
Protein Existence (PE) Number of entries
1 Evidence at protein level 98,403
2 Evidence at transcript level 57,025
3 Inferred from homology 386,093
4 Predicted 13,627
5 Uncertain 1,864

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 33
Updated entries 1,948
Unchanged entries 9,010
Total 9,406

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 715 715
Alternative products 25,139 25,139
Biophysicochemical properties 7,917 7,917
Biotechnological use 854 843
Catalytic activity 265,350 235,054
Caution 34,563 25,747
Cofactor 214,535 0
Developmental stage 11,839 11,838
Involvement in disease 6,817 4,554
Disruption phenotype 13,194 13,194
Domain 0 0
Enzyme regulation 14,289 14,287
Function 461,808 441,717
Induction 20,113 20,101
Mass spectrometry 0 0
Miscellaneous 38,037 35,171
Pathway 137,536 124,736
Pharmaceutical use 109 107
Polymorphism 1,254 1,198
Post-translational modification 54,980 40,907
RNA Editing 627 627
Sequence caution 60,740 44,053
Sequence similarities 505,306 501,160
Subcellular Location 671,157 0
Subunit structure 275,376 275,046
Tissue specificity 44,975 44,974
Toxic dose 662 608

Sequence Annotation (features)

Annotations Entries
Molecule processing 657,857 557,012
Chain 564,846 550,070
Initiator methionine 17,243 17,196
Peptide 11,383 7,839
Propeptide 14,050 11,989
Signal peptide 41,304 41,303
Transit peptide 9,031 8,915
Regions 1,324,996 320,662
Calcium binding 4,169 1,728
Coiled-coil 21,959 15,191
Compositional bias 58,841 31,638
DNA binding 11,587 10,480
Domain 0 0
Motif 42,115 27,630
Nucleotide binding 155,085 84,474
Repeat 104,382 14,700
Region 193,175 92,189
Topological domain 139,374 28,614
Transmembrane 368,969 76,953
Zinc finger 30,361 13,317
Sites 993,080 205,984
Active site 162,334 98,350
Metal binding 375,317 93,398
Binding site 399,292 105,298
Other 56,137 31,271
Amino acid modifications 524,544 114,971
Cross-link 23,478 8,393
Disulfide bond 122,570 33,154
Glycosylation 116,061 29,652
Lipidation 12,987 8,383
Modified residue 249,090 71,424
Non-standard residue 358 283
Natural variations 147,943 31,206
Natural variant 147,943 31,206
Alternative sequence 51,790 21,909
Experimental info 238,453 65,644
Mutagenesis 65,995 14,663
Non-adjacent residues 2,257 787
Non-terminal residue 12,348 9,462
Sequence conflict 153,424 47,234
Sequence uncertainty 4,429 788
Secondary structure 559,682 23,629
Helix 245,054 22,771
Turn 58,988 18,455
Beta strand 255,640 21,438

Citation usage

Citation type Citations Entries
Submission188,998163,255
Journal article1,010,050452,686
Book1,7031,680
Thesis434431
Patent199195
Unpublished observations397393
Online journal article621607

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 850,316 68,138

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS033,882
EMBL0545,400
PIR0113,593
RefSeq0462,080
UniGene096,095
3D structure databases
DisProt0703
PDB026,179
PDBsum026,179
ProteinModelPortal0447,822
SMR0439,468
Protein-protein interaction databases
BioGrid049,984
CORUM05,168
DIP017,304
ELM01,809
IntAct052,466
MINT021,762
STRING0332,036
Chemistry
BindingDB04,902
ChEMBL06,526
DrugBank03,637
GuidetoPHARMACOLOGY02,015
SwissLipids01,228
Protein family/group databases
Allergome01,136
CAZy08,524
ESTHER02,489
IMGT_GENE-DB0142
MEROPS011,381
MoonProt063
PeroxiBase0755
REBASE0397
TCDB06,584
mycoCLAP0354
PTM databases
CarbonylDB01,157
DEPOD0239
PhosphoSitePlus039,001
SwissPalm05,947
UniCarbKB0584
iPTMnet051,222
Polymorphism and mutation databases
BioMuta017,239
DMDM016,296
dbSNP012,437
2D gel databases
COMPLUYEAST-2DPAGE097
DOSAC-COBS-2DPAGE0145
OGP0374
REPRODUCTION-2DPAGE01,038
SWISS-2DPAGE01,178
UCD-2DPAGE0497
World-2DPAGE0918
Proteomic databases
EPD020,220
MaxQB029,726
PRIDE0141,706
PaxDb0124,289
PeptideAtlas032,068
ProMEX0453
TopDownProteomics02,967
Protocols and materials databases
DNASU018,881
Genome annotation databases
Ensembl050,151
EnsemblBacteria0335,312
EnsemblFungi028,734
EnsemblMetazoa010,338
EnsemblPlants021,155
EnsemblProtists04,784
GeneDB0657
GeneID0278,931
Gramene021,155
KEGG0476,023
PATRIC091,733
UCSC045,516
VectorBase0474
WBParaSite034
Organism-specific databases
ArachnoServer01,140
Araport015,611
CGD01,970
CTD073,823
ConoServer0866
DisGeNET014,615
EchoBASE04,159
EcoGene04,293
EuPathDB037,482
FlyBase05,840
GeneCards020,095
GeneReviews01,152
H-InvDB04,768
HGNC020,110
HPA016,795
LegioList0763
Leproma0669
MGI016,832
MIM014,965
MaizeGDB0505
MalaCards04,162
OpenTargets018,133
Orphanet03,286
PharmGKB018,329
PomBase05,129
PseudoCAP01,323
RGD07,945
SGD06,734
TAIR014,452
TubercuList02,150
VGNC03,514
WormBase04,566
Xenbase04,523
ZFIN03,005
dictyBase04,097
euHCVdb044
neXtProt020,182
Phylogenomic databases
GeneTree059,004
HOGENOM0390,904
HOVERGEN075,921
InParanoid0136,766
KO0402,589
OMA0416,058
OrthoDB0292,799
PhylomeDB095,531
TreeFam045,241
eggNOG0331,024
Enzyme and pathway databases
BRENDA012,093
BioCyc0154,223
Reactome036,463
SABIO-RK03,846
SIGNOR04,063
SignaLink03,026
UniPathway0123,434
Other
ChiTaRS020,439
EvolutionaryTrace016,614
GeneWiki010,282
GenomeRNAi022,002
PMAP-CutDB01,462
PRO095,146
Gene expression databases
Bgee056,224
CleanEx029,387
CollecTF0133
ExpressionAtlas051,074
Genevisible055,220
Ontologies
Family and domain databases
CDD0165,701
Gene3D0286,966
HAMAP0326,345
InterPro0537,770
PANTHER0253,563
PIRSF0107,641
PRINTS0117,218
PROSITE0297,659
Pfam0513,645
ProDom028,942
SFLD06,500
SMART0141,407
SUPFAM0374,926
TIGRFAMs0272,523

Web resource

5,767 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

    • Aliphatic
    • Acidic
    • Small hydroxy
    • Basic
    • Amide
    • Aromatic
    • Sulfur

    Miscellaneous Statistics

    16,248 entries are encoded on a mitochondrion, and 3,804 are encoded on a plasmid.

    12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 17 on unspecified types of plastid.