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Introduction

Number of entries
New entries 225
Updated entries 103,253
Unchanged entries 454,235
Total 557,713
Entries with updated sequences 25
With a fragmented AA sequence 9,151
With known alternative products 25,176
Protein Existence (PE) Number of entries
1 Evidence at protein level 98,669
2 Evidence at transcript level 57,241
3 Inferred from homology 386,324
4 Predicted 13,613
5 Uncertain 1,866

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 37
Updated entries 1,499
Unchanged entries 9,002
Total 9,426

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 719 719
Alternative products 25,176 25,176
Biophysicochemical properties 8,013 8,013
Biotechnological use 912 901
Catalytic activity 266,122 235,548
Caution 34,604 25,773
Cofactor 214,827 0
Developmental stage 11,896 11,895
Involvement in disease 6,837 4,578
Disruption phenotype 13,619 13,619
Domain 47,924 41,328
Enzyme regulation 14,587 14,585
Function 463,638 443,444
Induction 20,382 20,370
Mass spectrometry 0 0
Miscellaneous 38,182 35,200
Pathway 137,723 124,925
Pharmaceutical use 114 111
Polymorphism 1,289 1,233
Post-translational modification 55,375 41,108
RNA Editing 627 627
Sequence caution 60,903 44,154
Sequence similarities 506,181 502,036
Subcellular Location uniprot:(reviewed:yes) 0
Subunit structure 276,848 276,336
Tissue specificity 45,179 45,178
Toxic dose 668 611

Sequence Annotation (features)

Annotations Entries
Molecule processing 658,918 557,713
Chain 565,568 550,735
Initiator methionine 17,249 17,201
Peptide 11,456 7,871
Propeptide 14,128 12,040
Signal peptide 41,469 41,467
Transit peptide 9,048 8,932
Regions 1,331,808 321,810
Calcium binding 4,168 1,727
Coiled-coil 21,978 15,190
Compositional bias 58,888 31,685
DNA binding 11,600 10,492
Domain 192,904 118,869
Motif 42,395 27,798
Nucleotide binding 156,491 85,054
Repeat 105,048 14,694
Region 195,884 92,949
Topological domain 139,744 28,698
Transmembrane 369,689 77,133
Zinc finger 30,378 13,323
Sites 1,000,165 207,079
Active site 163,116 98,959
Metal binding 377,199 93,669
Binding site 402,997 106,068
Other 56,853 31,530
Amino acid modifications 525,030 115,208
Cross-link 23,570 8,420
Disulfide bond 123,551 33,387
Glycosylation 115,597 29,637
Lipidation 13,009 8,394
Modified residue 248,945 71,553
Non-standard residue 358 283
Natural variations 148,214 31,249
Natural variant 148,214 31,249
Alternative sequence 51,862 21,948
Experimental info 239,977 65,870
Mutagenesis 67,238 14,864
Non-adjacent residues 2,257 787
Non-terminal residue 12,374 9,492
Sequence conflict 153,679 47,305
Sequence uncertainty 4,429 788
Secondary structure 567,471 23,889
Helix 248,459 23,027
Turn 59,826 18,669
Beta strand 259,186 21,680

Citation usage

Citation type Citations Entries
Submission173,712155,216
Journal article1,029,916453,420
Book1,7361,713
Thesis436433
Patent201196
Unpublished observations408404
Online journal article621607

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 863,724 69,243

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS033,947
EMBL0546,066
PIR0113,651
RefSeq0462,667
UniGene096,247
3D structure databases
DisProt0703
PDB026,436
PDBsum026,436
ProteinModelPortal0448,010
SMR0443,752
Protein-protein interaction databases
BioGrid050,165
CORUM05,168
ComplexPortal04,286
DIP017,314
ELM01,809
IntAct051,294
MINT021,788
STRING0332,307
Chemistry
BindingDB05,013
ChEMBL06,527
DrugBank03,639
GuidetoPHARMACOLOGY02,028
SwissLipids01,258
Protein family/group databases
Allergome01,146
CAZy08,528
ESTHER02,493
IMGT_GENE-DB0142
MEROPS011,388
MoonDB0349
MoonProt0279
PeroxiBase0755
REBASE0397
TCDB06,690
mycoCLAP0354
PTM databases
CarbonylDB01,157
DEPOD0239
GlyConnect0495
PhosphoSitePlus039,008
SwissPalm07,256
UniCarbKB0584
iPTMnet051,233
Polymorphism and mutation databases
BioMuta017,240
DMDM016,296
dbSNP012,450
2D gel databases
COMPLUYEAST-2DPAGE097
DOSAC-COBS-2DPAGE0145
OGP0374
REPRODUCTION-2DPAGE01,038
SWISS-2DPAGE01,178
UCD-2DPAGE0497
World-2DPAGE0918
Proteomic databases
EPD020,233
MaxQB029,689
PRIDE0224,932
PaxDb0124,356
PeptideAtlas032,094
ProMEX0454
ProteomicsDB019,847
TopDownProteomics02,967
Protocols and materials databases
DNASU018,900
Genome annotation databases
Ensembl050,160
EnsemblBacteria0335,383
EnsemblFungi028,900
EnsemblMetazoa010,365
EnsemblPlants021,275
EnsemblProtists04,796
GeneDB0516
GeneID0279,920
Gramene021,275
KEGG0475,102
PATRIC091,781
UCSC045,531
VectorBase0497
WBParaSite034
Organism-specific databases
ArachnoServer01,140
Araport015,684
CGD01,970
CTD073,893
ConoServer0866
DisGeNET014,615
EchoBASE04,159
EcoGene04,293
EuPathDB037,707
FlyBase05,849
GeneCards020,146
GeneReviews01,152
H-InvDB04,769
HGNC020,158
HPA016,833
LegioList0763
Leproma0669
MGI016,840
MIM015,005
MaizeGDB0505
MalaCards04,435
OpenTargets018,149
Orphanet03,286
PharmGKB018,321
PomBase05,129
PseudoCAP01,323
RGD07,950
SGD06,734
TAIR014,519
TubercuList02,153
VGNC03,731
WormBase04,579
Xenbase04,540
ZFIN03,032
dictyBase04,097
euHCVdb044
neXtProt020,183
Phylogenomic databases
GeneTree059,176
HOGENOM0391,084
HOVERGEN075,943
InParanoid0136,872
KO0403,205
OMA0416,366
OrthoDB0293,165
PhylomeDB095,565
TreeFam045,267
eggNOG0331,301
Enzyme and pathway databases
BRENDA012,101
BioCyc0153,981
Reactome036,734
SABIO-RK03,925
SIGNOR04,067
SignaLink03,026
UniPathway0123,455
Other
ChiTaRS020,448
EvolutionaryTrace016,620
GeneWiki010,282
GenomeRNAi022,014
PMAP-CutDB01,462
PRO095,561
Gene expression databases
Bgee056,302
CleanEx029,387
CollecTF0133
ExpressionAtlas051,578
Genevisible055,226
Ontologies
Family and domain databases
CDD0166,066
Gene3D0291,845
HAMAP0326,928
InterPro0538,691
PANTHER0258,049
PIRSF0107,669
PRINTS0117,274
PROSITE0298,037
Pfam0514,288
ProDom028,951
SFLD06,502
SMART0141,597
SUPFAM0376,409
TIGRFAMs0272,599

Web resource

5,775 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

    • Aliphatic
    • Acidic
    • Small hydroxy
    • Basic
    • Amide
    • Aromatic
    • Sulfur

    Miscellaneous Statistics

    16,287 entries are encoded on a mitochondrion, and 3,805 are encoded on a plasmid.

    12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 17 on unspecified types of plastid.

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