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Overview

Proteins1,599
Proteome IDiUP000006900
Taxonomy561304 - Mycobacterium leprae (strain Br4923)
StrainBr4923
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000026685.1 from ENA/EMBL
Pan proteomei This proteome is part of the Mycobacterium leprae (strain TN) pan proteome (fasta)

An unculturable very slow-growing, acid-fast, obligate intracellular bacterium, which is non-motile and rod-shaped, Mycobacterium leprae is responsible for leprosy. Leprosy is primarily a granulomatous disease of the peripheral nerves and mucosa of the upper respiratory tract; skin lesions are the primary external symptom. Left untreated, leprosy can be progressive, causing permanent damage to the skin, nerves, limbs and eyes. Contrary to popular belief, leprosy does not actually cause body parts to simply fall off. People who have leprosy used to be forced to live in isolated colonies. It is now commonly believed that many of the people who were segregated into these communities were presumed to have leprosy, when they actually had syphilis. Leprosy is not highly infectious, as approximately 95% of people are immune; syphilis is more contagious. Before the 1940's leprosy was considered incurable until the development of the drug dapsone. M.leprae has however started to develop resistance to dapsone and so a new multiple-drug therapy (MDT) containing three drugs: dapsone, rifampicin and clofazimine is administered (adapted from Wikipedia).

Strain Br4923 was isolated in Brazil. It belongs to SNP type 4 subtype P according to a new phylogenetic grouping. Comparison of 4 genomes indicates they are 99.995% identical, differing by only 215 polymorphisms and by 5 pseudogenes. SNP typing suggests that leprosy which rose in Africa was introduced into Asia by both a southern route and a northerly route which followed the Silk Road. Introduction to the Americas probably occurred via European immigrants rather than over the Bering Strait (adapted from PMID 19881526).

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Componentsi

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Component nameGenome Accession(s)
Proteins
Chromosome1599

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