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Proteome nameStaphylococcus saprophyticus - Reference proteome
Proteome IDiUP000006371
StrainATCC 15305 / DSM 20229
Taxonomy342451 - Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000010125.1 from ENA/EMBL

Staphylococcus saprophyticus is the frequent cause of uncomplicated urinary tract infections (UTI) in young and middle-aged women. S.saprophyticus (strain ATCC 15305 / DSM 20229) was isolated from a human urine specimen. It harbors 2 plasmids pSSP1 and pSSP2. Its genome contains various mobile genetic elements including one prophage remnant, two IS431 elements, nine putative transposases, two staphylococcal cassettes (SCC), one of which carries a capsular polysaccharide synthesis locus, and one genomic island. The genomic island carries resistance determinants against streptomycin and fosfomycin instead of virulence factors. Genes involved in transport and regulation are abundant whereas there are fewer genes implicated in virulence than in S.aureus and S.epidermidis. Virulence factors such as coagulase, hemolysins, enterotoxins, extracellular matrix-binding proteins are absent. There is a unique cell wall-anchored protein involved in the adherence to uroepithelial cells. There are numerous transporter systems that evolved through paralog expansion. Unlike most uropathogenic bacteria, it has neither siderophores nor alpha-keto acid siderophore-producing systems. However, it possesses homologs of the NRAMP family. It lacks the potassium-importing ATPase. The agr locus, involved in regulation of virulence genes, is suprisingly well conserved conserved despite the absence of typical virulence factors.


DownloadView all proteins
Component nameGenome Accession(s)
Plasmid pSSP139
Plasmid pSSP218


  1. "Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection."
    Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M., Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.
    Proc. Natl. Acad. Sci. U.S.A. 2005:13272-13277(2005) [PubMed] [Europe PMC] [Abstract]