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Overview

Proteome nameAmycolatopsis mediterranei S699 - Reference proteome
Proteins9,551
Proteome IDiUP000006138
StrainS699
Taxonomy713604 - Amycolatopsis mediterranei (strain S699)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000220945.1 from ENA/EMBL

Amycolatopsis mediterranei is a soil bacterium which produces rifamycin B, an antibiotic used against various Mycobacterium infections. Strain S699 is a derivative of the original type strain (ATCC 13685) isolated in 1957 from a soil sample from a pine arboretum in France. It was first named Streptomyces mediterranei, later Nocardia mediterranea, and finally Amycolatopsis mediterranei.

A.mediterranei forms branching vegetative hyphae with a diameter of 0.5 to 2.0um, which tend to zig-zag. Spores, when formed, are found on the aerial hyphae and are ellipsoid to oblong, straight to flexous chains. Grows from 10 to 42 degrees Celsius, is non-acidfast, non-motile, aerobic and catalase-positive (adapted from 1986, Lechevalier et al., Int. J. Syst. Bacteriol. 36:29-37).

As of September 2013, 2 different groups have sequenced S699 using different techniques and assembly processes. The other S699 genome (CP003729) has 218 single nucleotide polymorphisms (SNPs) and 51 insertion/deletions compared to this one (CP002896), which the authors of the other study attribute to different assembly strategies (adapted from PMIDs 21914879 and 23012281).

Componentsi

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Component nameGenome Accession(s)
Proteins
Chromosome9551

Publications

  1. "Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699."
    Verma M., Kaur J., Kumar M., Kumari K., Saxena A., Anand S., Nigam A., Ravi V., Raghuvanshi S., Khurana P., Tyagi A.K., Khurana J.P., Lal R.
    J. Bacteriol. 2011:5562-5563(2011) [PubMed] [Europe PMC] [Abstract]