Proteomes - Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
|Proteome name||Actinoplanes sp. (strain 50/110) - Reference proteome|
|Strain||ATCC 31044 / CBS 674.73 / SE50/110|
|Taxonomy||134676 - Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)|
|Last modified||October 9, 2016|
Actinoplanes sp. SE50/110 is an actinomycete originally isolated near Ruiru, Kenya in 1969. Derivatives of this strain are used in the industrial produciton of the alpha-glucosidase inhibitor acarbose, (O-[4,6-dideoxy-4[1 s-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2-cyclohexen-1-yl]-amino-alpha-D-glucopyranosyl]-(1-->4)- O-alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose). Acarbose has been used since 1990 in the therapy of diabetes type II, in order to enable patients to better control blood sugar contents while living with starch-containing diets. With a mean G+C content of 71.32% the genome is difficult to sequence, but after considerable effort it has been determined to consist of 9,239,851 bp (adapted from PMIDs 21536083, 14669056 and http://188.8.131.52/IMG/pdf/Projekt_BIE_Schwientekr_110609.pdf).