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Overview

StatusReference proteome
Proteins8,249
Proteome IDiUP000005440
Taxonomy134676 - Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110)
StrainATCC 31044 / CBS 674.73 / SE50/110
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000237145.1 from ENA/EMBL

Actinoplanes sp. SE50/110 is an actinomycete originally isolated near Ruiru, Kenya in 1969. Derivatives of this strain are used in the industrial produciton of the alpha-glucosidase inhibitor acarbose, (O-[4,6-dideoxy-4[1 s-(1,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2-cyclohexen-1-yl]-amino-alpha-D-glucopyranosyl]-(1-->4)- O-alpha-D-glucopyranosyl-(1-->4)-D-glucopyranose). Acarbose has been used since 1990 in the therapy of diabetes type II, in order to enable patients to better control blood sugar contents while living with starch-containing diets. With a mean G+C content of 71.32% the genome is difficult to sequence, but after considerable effort it has been determined to consist of 9,239,851 bp (adapted from PMIDs 21536083, 14669056 and 87.106.29.192/IMG/pdf/Projekt_BIE_Schwientekr_110609.pdf).

Componentsi

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Component nameGenome Accession(s)
Proteins
Chromosome8249

Publications

  1. "The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110."
    Schwientek P., Szczepanowski R., Kalinowski J., Klein A., Selber K., Wehmeier U.F., Stoye J., Puehler A.
    Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases

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