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Overview

Proteome nameShigella sonnei
Proteins4,068
Proteome IDiUP000002529
StrainSs046
Taxonomy300269 - Shigella sonnei (strain Ss046)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000092525.1 from ENA/EMBL
Pan proteomei This proteome is part of the Shigella dysenteriae pan proteome (fasta)

Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35'000-270'000 years ago and may not constitute a genus. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. Shigella sonnei is largely associated with epidemic episodes in industrialized nations. Shigella sonnei (strain Ss046) was isolated from epidemics in China during the 1950's. The Shigella pathogenicity island SHI-1 is absent from the strain Ss046 but SHI-2 is present but unlinked with the selC gene. It has lost flagellar function due to muations in several different genes. It possesses remnants of the Stx-phage phi P27.

Componentsi

DownloadView all proteins
Component nameGenome Accession(s)
Proteins
Chromosome3854
Plasmid pSS_046214
Plasmid pSS046_spC1
Plasmid pSS046_spB8
Plasmid pSS046_spA5

Publications

  1. "The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei."
    Jiang Y., Yang F., Zhang X., Yang J., Chen L., Yan Y., Nie H., Xiong Z., Wang J., Dong J., Xue Y., Xu X., Zhu Y., Chen S., Jin Q.
    Plasmid 2005:149-159(2005) [PubMed] [Europe PMC] [Abstract]