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Proteome nameClostridium botulinum Langeland
Proteome IDiUP000002410
StrainLangeland / NCTC 10281 / Type F
Taxonomy441772 - Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000017065.1 from ENA/EMBL
Pan proteomei This proteome is part of the Clostridium botulinum Sanger pan proteome (fasta)

Clostridium botulinum produces botulinum neurotoxin, one of deadliest toxins known. It inhibits acetylcholine release in neuromuscular junctions, causing paralysis by inhibiting muscle contraction. In most cases the affected person dies of asphyxiation or heart failure. Strains of C. botulinum are physiologically heterogeneous, and four distinct phenotypic groups (I to IV) are recognized. These four metabolically distinct groups do not, however, necessarily correlate with the serological specificities of the botulinum neurotoxin produced, which are classified into 7 serotypes, A-F. The type A toxin is used in minute doses to treat both painful muscle spasms and as a cosmetic treatment to temporarily remove frown lines between eyebrows.

Strain Langeland is a representative of the Group I (proteolytic) botulinum toxins producing bacteria. Group I strains produce one or two toxins of type A, B or F; strain Langeland produces type F neurotoxin. Food-borne, infant and wound botulism can all be caused by Group I strains. It was identified in 1958 from home-prepared liver paste involved in an outbreak of food-borne botulism on the island of Langeland, Denmark.


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Component nameGenome Accession(s)
Plasmid pCLI24