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Overview

Proteome nameCandidatus Arthromitus sp. SFB-mouse-Japan - Reference proteome
Proteins1,487
Proteome IDiUP000001636
StrainSFB-mouse-Japan
Taxonomy1029718 - Arthromitus sp. (strain SFB-mouse-Japan)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000270205.1 from ENA/EMBL

Segmented filamentous bacteria (SFBs), which are clostridia-related Gram-positive bacteria, are non-culturable inhabitants of the terminal ilea of the mammalian intestine well known for their unique morphology and tight attachment to intestinal epithelial cells. Their characteristic prevalence at weaning periods and unique morphology of being tightly attached to the epithelial cells around Peyer's patches strongly suggest their involvement in the post-natal maturation of the gut immune system, especially the induction of Th17 lymphocytes (proinflammatory T helper lymphocytes). This mouse SFB genome comprises a single circular chromosome which lacks genes for the biosynthesis of almost all amino acids, vitamins/cofactors and nucleotides, but contains a full set of genes for sporulation/germination and, unexpectedly, for chemotaxis/flagella-based motility. These findings suggest a hitherto unsuspected triphasic lifestyle of the SFB, which comprises two types of vegetative (swimming and epicellular parasitic) phases and a dormant (spore) phase. SFBs encode four types of flagellin, three of which are recognized by Toll-like receptor 5 and could elicit the innate immune response (adapted from PMID 21791478).

Componentsi

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Component nameGenome Accession(s)
Proteins
Chromosome1487

Publications

  1. "The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing."
    Kuwahara T., Ogura Y., Oshima K., Kurokawa K., Ooka T., Hirakawa H., Itoh T., Nakayama-Imaohji H., Ichimura M., Itoh K., Ishifune C., Maekawa Y., Yasutomo K., Hattori M., Hayashi T.
    DNA Res. 2011:291-303(2011) [PubMed] [Europe PMC] [Abstract]