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Overview

Proteome nameAjellomyces capsulatus G186AR - Reference proteome
Proteins9,214
Proteome IDiUP000001631
StrainG186AR / H82 / ATCC MYA-2454 / RMSCC 2432
Taxonomy447093 - Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000150115.1 from ENA/EMBL

Ajellomyces capsulatus also known as Histoplasma capsulatum is a thermal dimorphic fungus that causes histoplasmosis, a potentially fatal disease of the lungs. The disease was first discovered by Samuel Darling in 1903, hence its other common name, Darling's disease fungus.

In moist soil that is rich in bird or bat guano at 25C, H. capsulatum exists in a filamentous mycelia form. Infection can arise from disturbing spore-rich soil. Spores are especially prevalent in the Ohio and Mississippi river valley regions. Outbreaks have been seen after earthquakes as spores are thrown into the air by the violent movement of the earth. Once inhaled, the spores develop into a yeast-like growth form in response to the higher temperature.

Approximately 95% of cases of histoplasmosis are unapparent, subclinical or benign. Traditionally, positive identification required the yeast to be grown at 37C on enriched media, however culture identification by the exoantigen test is now the method of choice.

The Ajellomyces capsulatus genome was sequenced by The Broad Institute using Sanger shotgun sequencing (ENA: AAJI00000000.1). It is predicted to contain 9,313 protein-coding genes. The reference proteome for this species is comprised of the G186AR strain.

Componentsi

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Component nameGenome Accession(s)
Proteins
Unassembled WGS sequence9214