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Overview

Proteome nameMycobacterium tuberculosis ATCC 25618 - Reference proteome
Proteins3,993
Proteome IDiUP000001584
StrainATCC 25618 / H37Rv
Taxonomy83332 - Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Last modifiedFebruary 4, 2017
Genome assembly and annotationi GCA_000195955.2 from ENA/EMBL
Pan proteomei This proteome is part of the Mycobacterium tuberculosis ATCC 25618 pan proteome (fasta)

Acid-fast, obligate aerobic, non-motile, rod-shaped bacterium, this is the causative agent of tuberculosis. Tuberculosis is, to this day, according to the WHO, the leading killer of adults, with approximately 2 million deaths annually worldwide. It is estimated that 8 million people are infected each year. A large part of its success as a pathogen is due to its ability to persist in a dormant or latent form for years or even decades, with a concomitant absence of clinical symptoms. This non-replicating persistent form is refractory to most drugs, it may be induced by hypoxia (oxygen depletion) and/or nitric oxide exposure. Up to one-third of the world's population is thought to be latently infected. An additional problem is the emergence of drug resistant strains, mainly because people do not complete their treatment plans or have been incorrectly treated and so have remained infectious.

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Componentsi

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Component nameGenome Accession(s)
Proteins
Chromosome3993