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Proteome nameMacrococcus caseolyticus - Reference proteome
Proteome IDiUP000001383
Taxonomy458233 - Macrococcus caseolyticus (strain JCSC5402)
Last modifiedFebruary 5, 2017
Genome assembly and annotationi GCA_000010585.1 from ENA/EMBL
Pan proteomei This proteome is part of the Macrococcus caseolyticus pan proteome (fasta)

Macrococcus caseolyticus (strain JCSC5402) is a large gram positive coccus isolated from animal meat in a supermarket. It is related to the Staphylococcus. It possesses a small chromosome (2.1 MB) and 8 plasmids, and lacks many sugar and amino acid metabolism pathways and a plethora of virulence genes that are present in S. aureus. M. caseolyticus possesses a series of oxidative phosphorylation machineries that are closely related to those in the family Bacillaceae. It has also a probable primordial form of a Macrococcus methicillin resistance gene complex, mecIRAm, on one of its eight. This is the first finding of a plasmid-encoding methicillin resistance gene. M. caseolyticus is considered to reflect the genome of ancestral bacteria before the speciation of staphylococcal species and may be closely associated with the origin of the methicillin resistance gene complex of the notorious human pathogen methicillin-resistant S. aureus. Unlike staphylococcal species, M. caseolyticus do not cause human or animal diseases. (Adaptated from PMID: 19435847).


DownloadView all proteins
Component nameGenome Accession(s)
Plasmid pMCCL114
Plasmid pMCCL268
Plasmid pMCCL31
Plasmid pMCCL42
Plasmid pMCCL54
Plasmid pMCCL64
Plasmid pMCCL75
Plasmid pMCCL83


  1. "Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci."
    Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K.
    J. Bacteriol. 2009:1180-1190(2009) [PubMed] [Europe PMC] [Abstract]