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Overview

StatusReference proteome
Proteins4,103
Proteome IDiUP000001006
Taxonomy623 - Shigella flexneri
Strain301 / Serotype 2a
Last modifiedApril 5, 2018
Genome assembly and annotationi GCA_000006925.2 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35'000-270'000 years ago and may not constitute a genus. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

Componentsi

DownloadView all proteins
Component nameGenome Accession(s)
Proteins
Chromosome3877
Plasmid pCP301248

Publications

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 2002:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]

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