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Overview

Proteome nameBorrelia recurrentis
Proteins977
Proteome IDiUP000000612
StrainA1
Taxonomy412418 - Borrelia recurrentis (strain A1)
Last modifiedFebruary 5, 2017
Genome assembly and annotationi GCA_000019705.1 from ENA/EMBL
Pan proteomei This proteome is part of the Borrelia burgdorferi DSM 4680 pan proteome (fasta)

Relapsing fever (RF) is a disease caused by several spirochetes of the genus Borrelia. Relapsing fever borrelioses are characterized by recurrent febrile episodes and spirochetemia. There are 2 forms; louse-borne relapsing fever (also known as urban or epidemic RF) is caused by Borrelia recurrentis, and is transmitted by the body louse Pediculus humanus humanus. It currently known in Ethiopia. Endemic tick-borne relapsing fever (TBRF) is a zoonotic disease transmitted worldwide by softbody ticks of the genus Ornithodoros. It is caused by at least 15 distinct Borrelia species throughout the world.

Borrelia recurrentis strain A1 was isolated from an adult with RF in Ethiopia. RF causes fewer relapses that TBRF but has a higher spontaneous mortality rate despite antibiotics. Previous work suggested that B.recurrentis was very closely related to B.duttonii; the current sequencing project suggests that in fact B.recurrentis should be considered a strain of B.duttonii that is undergoing considerable gene decay. Decay is probably due at least in part to mutated recA and mutS genes in A1. All 6 plasmids in strain A1 have a counterpart in B.duttonii strain Ly (BORDL).

Componentsi

DownloadView all proteins
Component nameGenome Accession(s)
Proteins
Chromosome799
Plasmid pl12491
Plasmid pl2317
Plasmid pl3317
Plasmid pl3515
Plasmid pl3719
Plasmid pl5328
Plasmid pl63

Publications

  1. "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
    Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 2008:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]