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Program › Animal toxin annotation program

Statistics

UniProt release 2013_05 of May-01, 2013 contains 540,052 reviewed entries.

Total number of reviewed animal toxin entries: 5,042 .

Total number of reviewed venom protein entries: 5,580 .

Common name Scientific name Toxins Proteins
found in
venom		 Species
producing
toxins		 Species
secreting
venom
Snakes Serpentes 1,690 2,034 163 190
Spiders Araneae 1,282 1,341 90 90
Snails Gastropoda 1,059 1,057 94 92
Scorpions Scorpiones 693 836 64 69
Sea anemones Actiniaria 141 0 37 0
Insects Hexapoda 53 221 31 71
Lizards Anguimorpha 32 37 7 7
Fishes Teleostei 26 12 8 4
Scolopendra Scolopendridae 23 26 2 4
Mammals Mammalia 7 6 2 1
Hydra Hydroida 4 0 2 0
Toad Amphibia 5 4 3 2
Mites Acari 3 0 2 0
Starfishes Asteroidea 3 3 1 1
Worms Cerebratulus 3 0 1 0
Medusae Rhopilema 1 0 1 0
Jellyfishes Cubozoa 5 0 4 0
other metazoans - 12 3 6 2
All animals Metazoa 5,042 5,580 541 533

Venom protein targets in UniProtKB/Swiss-Prot distributed by taxonomical group. The idea for the table originates from the nomenclature proposition made by King et al. 2008 (PMID:18619481). The table proposed in this paper has been completed and links between venom proteins and targets have been added. Since this table may also help in nomenclature discussions, the descriptors (Greek letter that specifies the biological function) proposed by these authors are also indicated (see 2nd column). Note that multiple descriptors used for sodium channels are due to different modes of action on this channel. The targets are firstly ordered by types: ion channels, receptors (7TM and 1TM) and transporters, and secondly by abundance.

target: ion channel (voltage-gated and transmitter-gated) descriptor snake scorpion spider cone snail insect sea anemone all
voltage-gated sodium (Nav) channel beta, delta, iota, mu 19 342 140 87 3 66 666
potassium channel inhibitor (Includes the following 4 channels: KIR, K2P, Kv and KCa as targets) - 30 251 97 40 6 18 457
- voltage-gated potassium (Kv) channel kappa 12 99 69 20 0 12 213
- calcium-activated potassium (KCa) channel lambda 10 7 0 0 0 0 17
- inward-rectifier potassium (KIR) channel eta 0 0 0 0 1 0 1
- two-pore domain potassium (K2P) channel theta 0 0 0 0 0 0 0
nicotinic acetylcholine receptor alpha, psi 226 0 0 138 0 0 364
calcium channel inhibitor (Includes CaV and Ryr) - 50 19 107 73 6 0 268
- voltage-gated calcium (Cav) channel omega 11 3 101 67 5 0 188
- ryanodine receptor (RyR) phi 8 13 0 0 0 0 22
- P2RX receptor omicron 0 0 2 0 0 0 2
chloride channel inhibitor (Includes CLCN, CFTR and GABA(A) as targets) - 5 18 0 0 1 0 65
- voltage-gated chloride channels (CLCN) epsilon 0 2 0 0 0 0 2
- CFTR channel LAMBDA - in upper case 3 1 0 0 0 0 4
- GABA(A) receptor SIGMA - in upper case 2 0 0 0 1 0 3
glutamate receptor GAMMA - in upper case 0 0 2 15 0 0 17
HCNa nonspecific cation channel gamma 0 0 0 7 0 0 7
cyclic nucleotide-gated channel zeta 9 0 0 0 0 0 9
transient receptor potential (TRP) channel tau 0 0 4 0 0 1 5
acid-sensing ion (ASICs) channel pi 4 0 1 0 0 1 6
5-HT receptor sigma 0 0 0 1 0 0 1
target: receptor 7TM descriptor snake scorpion spider cone snail insect sea anemone all
muscarinic acetylcholine receptor - 0 0 0 0 0 0 0
adrenoceptor rho 4 12 0 1 0 0 18
bradykinin receptor - 6 0 1 0 6 0 16
vasopressin/oxytocin receptor upsilon 0 0 0 5 0 0 5
endothelin receptor xi 6 0 0 0 0 0 6
vasoactive intestinal polypeptide receptor - 0 0 0 0 0 0 4
glucagon-like peptide receptor - 0 0 0 0 0 0 3
cholecystokinin receptor - 0 0 0 0 0 0 1
neurotensin receptor nu 0 0 0 3 0 0 3
target: receptor 1TM descriptor snake scorpion spider cone snail insect sea anemone all
vascular endothelial growth factor receptor - 15 0 0 0 0 0 15
epidermal growth factor receptor OMEGA - in upper case 0 0 0 0 0 4 4
target: transporter descriptor snake scorpion spider cone snail insect sea anemone all
noradrenaline transporter chi 0 0 0 8 0 0 8
glutamate transporter - 0 0 1 0 0 0 1

Snake venom proteins - 2,034 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 65.5%
at transcript level 32.2%
inferred from homology 2.3%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,750 1,650 unique 86%
General annotation 2,034 12,923 100%
Function 1,884 2,017 92.6%
Catalytic activity 504 504 24.8%
Subcellular location 2,033 2,052 100%
Toxic dose 261 285 12.8%
Sequence annotation 2,029 21,592 99.8%
Amino acid modifications 1,835 9,991 90.2%
Cross-references 2,034 23,737 95.2%
EMBL 1,195 1,496 58.8%
InterPro 1,772 5,066 87.1%
PDB 228 506 11.2%

100% of reviewed snake venom proteins entries are annotated with at least one keyword .

99.5% of reviewed snake venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Snail venom proteins - 1,057 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 34.3%
at transcript level 58.8%
inferred from homology 6.6%
predicted N/A
uncertain 0.2%

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,002 371 unique 94.8%
General annotation 1,057 5,573 100%
Function 491 494 46.5%
Catalytic activity 3 3 0.3%
Subcellular location 1,057 1,058 100%
Toxic dose 2 2 0.2%
Sequence annotation 1,043 6,729 98.7%
Amino acid modifications 970 3,509 91.8%
Cross-references 1,057 4,136 91.7%
EMBL 669 909 63.3%
InterPro 630 815 59.6%
PDB 61 118 5.8%
Conoserver 832 914 78.7%

100% of reviewed snail venom proteins entries are annotated with at least one keyword .

100% of reviewed snail venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Scorpion venom proteins - 836 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 61.7%
at transcript level 36.6%
inferred from homology 1.7%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 775 550 unique 92.7%
General annotation 836 3,924 100%
Function 740 767 88.5%
Catalytic activity 11 11 1.3%
Subcellular location 836 868 100%
Toxic dose 75 76 9%
Sequence annotation 830 4,600 99.3%
Amino acid modifications 675 2,506 80.7%
Cross-references 832 5,712 87.9%
EMBL 430 549 51.4%
InterPro 587 1,379 70.2%
PDB 87 143 10.4%

100% of reviewed scorpion venom proteins entries are annotated with at least one keyword .

99.5% of reviewed scorpion venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Spider venom proteins - 1,341 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 44.7%
at transcript level 51.8%
inferred from homology 3.5%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,271 333 unique 94.8%
General annotation 1,341 7,458 100%
Function 1,052 1,054 78.4%
Catalytic activity 211 213 15.7%
Subcellular location 1,339 1,355 99.9%
Toxic dose 94 103 7%
Sequence annotation 1,331 8,298 99.3%
Amino acid modifications 1,148 3,675 85.6%
Cross-references 1,341 6,041 95.6%
EMBL 945 1,240 70.5%
InterPro 954 1,201 71.1%
PDB 50 68 3.7%
ArachnoServer 755 763 56.3%

100% of reviewed spider venom proteins entries are annotated with at least one keyword .

99.9% of reviewed spider venom proteins entries are annotated with at least one GO (Gene Ontology ) term.